Preparation, characterization and featuring of an inclusion complex of nerol with β-cyclodextrin

  • Authors

    • Mayara Coêlho Post-graduate Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Piauí, Brazil
    • Herlane da Silva Integral Diferential College, Teresina, Piauí, Brazil
    • Muhammad Islam Post-graduate Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Piauí, Brazil
    • Vicente Viana Laboratory of Treatment of Materials, Federal Institute of Piauí, Teresina, Piauí, Brazil
    • Ana Amélia Melo-Cavalcante Post-graduate Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Piauí, Brazil
    2017-07-16
    https://doi.org/10.14419/ijm.v5i2.7933
  • Nerol, Monoterpene, Î’-Cyclodextrin, Inclusion Complex, Solubility.
  • Abstract

    Nerol is an acyclic type monoterpene with important biological activities. However, the low solubility in aqueous media is a limiting factor for its user. Cyclodextrins have been widely used in order to improve the solubility, stability and bioavailability of nonpolar molecules through the formation of inclusion complexes. Thus, the present study consists in the development of nerol inclusion complex in combination with the β-cyclodextrin (β-CD) followed by characterizing by thermal analysis and spectrophotometric absorption in the infrared (FTIR). The results suggest a complexation of nerol with β-CD having detours and changed the intensity of various bands. The thermo gravimetric curve of CI found to indicate an output of solvating water molecules from the complex cavity formed for replacement of drug molecules probably included. Thus, it is concluded a possibility to obtain inclusion complexes of nerol monoterpene with β-CD, which will increase its solubility and facilitate delivery process.

  • References

    1. [1] Rodrigues MM. 2013. Inventory of medicinal plants of viva pharmacy program peaks city. 2013. 42 f. Work Completion of course (Graduation in Biological Sciences). Federal University of Piaui. Peaks 2013. Available at: <http://www.ufpi.br/subsiteFiles/picos/arquivos/files/monografia (2).pdf>.
      [2] Carvalho CS. 2013. Gastroprotective effect of monoterpenes present in medicinal plants of the cerrado and caatinga in models of gastric lesions in rodents. Teresina 2013, p.1-3.
      [3] Knaak N, Fiuza LM. 2010. Potential of essential oils of plants on insects and microorganisms control. São Leopoldo 5:20-123, 2010. Available at: < http://www.unisinos.br/blogs/ppg-biologia/files/2011/05/art08_knaak_et_al.pdf>.
      [4] Angelis CD. 2012. Evaluation of gastric and duodenal protection nerol monoterpene in rodents. 2012. 73 f. Dissertation (Masters in Biological Sciences) - Universidade Estadual Paulista, Botucatu 2012. Available at: <http://base.repositorio.unesp.br/bitstream/handle/11449/91622/angelis_cd_me_botib.pdf?sequence=1>.
      [5] Marciel MV, et al. 2011. Insecticidal activity of essential oils of Lippia idoidese coriandrumsativum on Lutzomyia longipalpis. Ceará 19:77-87.
      [6] Melo NF, et al. 2007. Preparation and initial characterization of inclusion complex of nitrofurazone and 2-hydroxypropyl-cyclodextrin. Rev. Ciênc. Farm. Basic Appl. São Paulo 28:35-44. Available at: <http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/viewFile/343/328>.
      [7] Silva JLGH. 2014. Synthesis and characterization of ternary complex Β-cyclodextrin: cholecalciferol: metal ions. 2014 77F. Dissertation (Masters in Engineering and Science) - Federal University of Paraná, Curitiba, 2014.
      [8] Feuzer PE. 2012. Encapsulation simultaneous magnetic nanoparticles (NPMs) zinc phthalocyanine (ZnPc) via polymerization in miniemulsion. 2012. 120f. Dissertation (Grasuação in Chemical Engineering) - Federal University of Santa Catarina, Florianópolis, 2012.
      [9] Arrais MAS. 2012. Collection and physicochemical characterization of inclusion complex dapsone: βcd and dapsone: sbeβcd to increase solubility in pharmaceutical form. 2012. 93 f. Dissertation (Master in Pharmaceutical Sciences) - Federal University of Piauí, Teresina, 2012. Available at: <http://www.ufpi.br/subsiteFiles/ppgcf/arquivos/files/9a_dissertacao_monica_amaral.PDF>.
      [10] Zeni D. 2005. Determination of propranolol hydrochloride in drugs by infrared spectroscopy with multivariate calibration (PLS). 2005. 64f. Dissertation (Master in Chemistry) - Federal University of Santa Maria, in 2005.
      [11] Nascimento JL. 2013. Inclusion complex of hexane extract of PlatoniainsignisMart and β-cyclodextrin: characterization and evaluation of gastroprotective and in vitro antioxidant activities. 2013. Dissertation (Master in Pharmaceutical Sciences) - Federal University of Piauí, Teresina, 2013.
      [12] Novak C, Ehen Z, Fodor M, Jicsinszky L, Orgovanyi J. 2006. Aplication of combined thermoanalytical techniques in the investigation of cyclodextrin inclusion complexs. J. Therm. Anal. Calorim. 84:693-701. https://doi.org/10.1007/s10973-005-7605-8.
      [13] Aguiar UN. 2014. Preparation and characterization of inclusion complex of essential oil of β-cyclodextrin crotonzehntnericom. Química Nova 37:50-55. https://doi.org/10.1590/S0100-40422014000100010.

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  • How to Cite

    Coêlho, M., da Silva, H., Islam, M., Viana, V., & Melo-Cavalcante, A. A. (2017). Preparation, characterization and featuring of an inclusion complex of nerol with β-cyclodextrin. International Journal of Medicine, 5(2), 195-198. https://doi.org/10.14419/ijm.v5i2.7933

    Received date: 2017-06-05

    Accepted date: 2017-07-07

    Published date: 2017-07-16