Melkersson–Rosenthal Syndrome: The Role of The Dentist In Early Diagnosis: A Case Report

  • Authors

    • Khelifa Moussa Oral Pathology and Surgery Department, CHU, Oran, Algeria and Department of Dental Medicine / Faculty of Medicine / Oran University, Oran, ‎Algeria
    • Boukerche Amel Oto-Rhino-Laryngology, Head and Neck Surgery Department, EHU, Oran, Algeria and Department of Medicine / Faculty of Medicine / Oran University, Oran, Algeria
    • Tabeti - Bentahar Cherifa Faiza Oral Pathology and Surgery Department, CHU, Oran, Algeria and Department of Dental Medicine / Faculty of Medicine / Oran University, Oran, ‎Algeria
    https://doi.org/10.14419/mhzd3p96

    Received date: December 28, 2025

    Accepted date: February 6, 2026

    Published date: February 12, 2026

  • Facial Palsy; Histopathology; Macrocheilitis; Melkersson–Rosenthal Syndrome; Orofacial ‎Granulomatosis

  • Abstract

    Melkersson–Rosenthal syndrome (MRS) is a rare disorder that belongs to the group of orofacial granulomatosis. It is classically defined by a clinical triad consisting of recurrent ‎orofacial edema, peripheral facial nerve palsy, and fissured tongue, although the complete ‎form is uncommon. Diagnosis relies mainly on histopathological examination, which demonstrates non-caseating granulomatous inflammation. The etiology and pathophysiology of MRS ‎remain unclear, and current treatments are essentially symptomatic, with variable efficacy ‎and frequent recurrences. Dentists play a crucial role in early diagnosis, as oral manifestations ‎are often the first signs of the disease. This article reports a clinical case and discusses the ‎diagnostic approach and therapeutic management of MRS based on a review of the ‎literature‎.

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  • How to Cite

    Moussa , K. ., Amel, B. ., & Cherifa Faiza, T. .-. B. (2026). Melkersson–Rosenthal Syndrome: The Role of The Dentist In Early Diagnosis: A Case Report. International Journal of Medicine, 14(1), 17-20. https://doi.org/10.14419/mhzd3p96