A Case Report of Primary Pleural Melanoma
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https://doi.org/10.14419/e7fcj783
Received date: September 28, 2025
Accepted date: November 26, 2025
Published date: December 5, 2025
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Pleural; Melanoma; Ultrasound-Guided Biopsy. -
Abstract
Primary malignant pleural melanoma is an extremely rare neoplasm, and to the best of our knowledge, there have been 40 cases of primary pulmonary melanoma reported, but only 8 cases of primary pleural melanoma in the literature. We herein report a rare case in which cytological and immunocytochemical analyses of pleural fluid and an ultrasonography (US)-guided biopsy of a pleural lesion were useful for diagnosing primary pleural melanoma. This case highlights the importance of careful physical examinations, cytomorphologic and immunocytochemical analyses of pleural fluid, as well as the utility of US-guided biopsy of the pleural lesions in the diagnosis of primary pleural melanoma.
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References
- F. Rivière, A. Bonnichon-Py, H. Le Floch, et al. Malignant melanoma of the lung: primary or metastasis? Rev Mal Respir 2010; 27: 88-92. https://doi.org/10.1016/j.rmr.2009.05.001.
- Kunkel O. F., Torrey E. Report of a case of primary melanotic sarcoma of the lung presenting difficulties in differentiating from tuberculosis. New York State Journal of Medicine. 1916 ; 16 :198–201.
- Y. Feng, J. Zhao, Q. Yang et al., “Pulmonary melanoma and “crazy paving” patterns in chest images : a case report and literature review,” BMC Cancer, vol. 16, no. 1, article no. 592, 2016. https://doi.org/10.1186/s12885-016-2630-5.
- Smith S, Opipari MI. Primary pleural melanoma. A first reported case and literature reivew. J Thorac Cardiovasc Surg 1978 ;75 :827–31. https://doi.org/10.1016/S0022-5223(19)39595-9.
- Agarwal P, Nambiyar K, Manju Kaushal, Bhardwaj M. Primary malignant melanoma of pleura. A case report and literature review. Diagn Cytopa-thol 44 : 648-652, 2016. https://doi.org/10.1002/dc.23497.
- Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. Cancer J Clin 2005 ;55 :74–108. 1. Smith S, Opipari MI. Primary pleural mela-noma. A first reported case and literature review. J Thorac Cardiovasc Surg 75: 827-831, 1978. https://doi.org/10.3322/canjclin.55.2.74.
- Mohanty PP, Pasricha R, Gupta A, Jain M, Datta NR. Malignant melanoma of pleura in a patient with giant congenital “bathing suit” hairy nevus. Int J Clin Oncol 9 : 410-412, 2004. https://doi.org/10.1007/s10147-004-0427-z.
- Ohata Y, Haga T, Ogata S, Nakanishi K, Kawai T. Malignant amelanotic melanoma of the pleura without primary skin lesion: an autopsy case re-port. Acta Med Okayama 63 : 379-384, 2009.
- Shameem M, Akhtar J, Baneen U, et al. Malignant melanoma presenting as an isolated pleural effusion. Monaldi Arch Chest Dis 75 : 138-140, 2011. https://doi.org/10.4081/monaldi.2011.228.
- Cheng L, Nie J, Li J, Wang J, Jiang K. Primary pleural malignant melanoma with rapid progression. Ann Thorac Surg 98: 334-336, 2014. https://doi.org/10.1016/j.athoracsur.2013.09.065.
- Wang Q, Chen J, Dassarath M, et al. Primary malignant melanoma of the pleura with rapid progression: a case report and literature review. Oncol Lett 9: 2713-2715, 2015. https://doi.org/10.3892/ol.2015.3104.
- Um SW, Yoo CG, Lee CT, Han SK, Shim YS, Kim YW. Apparent primary pleural melanoma: case report and literature review. Respir Med 97: 586-587, 2003. https://doi.org/10.1053/rmed.2003.1482.
- Dountsis A, Zisis C, Karagianni E, et al. Primary malignant melanoma of the lung : a case report. World J Surg Oncol 2003 ;1:26. https://doi.org/10.1186/1477-7819-1-26.
- Pan XD, Zhang B, Guo LC, et al. Primary malignant melanoma of the lung in the elderly : case report and literature review. Chin Med J (Engl) 2010 ;123 :1815–7. https://doi.org/10.3760/cma.j.issn.0366-6999.2010.13.040.
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How to Cite
Kambouche, F. ., Ali, I. S. ., & Belabbas, I. . (2025). A Case Report of Primary Pleural Melanoma. International Journal of Medicine, 13(2), 6-8. https://doi.org/10.14419/e7fcj783
