Squamous cell carcinoma (SCC) of the renal pelvis following chronic nephrolithiasis; presented with feature suggesting xanthogranulomatous pyelonephritis

  • Authors

    • Mosab Abdalla Ali Alzubier Prince Sattam Ibn Abdualaziz university, faculty of medicine and university hospital
    • Ahmed Eltyeb Ibrahim kharoum teaching hospital
    • Sami Mahjoub Taha university of gezira, faculty of medicine
    2020-12-26
    https://doi.org/10.14419/ijm.v9i1.31239
  • Squamous Cell Carcinoma, Renal Pelvis, Nephrectomy, Nephrolithiasis, Case Report.
  • Background: Squamous cell carcinoma (SCC) which originated in the urothelium of the urological system is not uncommon; however, it is rare in the renal pelvis. Additionally, it is hard to be diagnosed without high clinical suspicion.

    Case summary: A-66-years old female presented with left loin pain for 6 years, hematuria, and fever for months. Examination revealed no abnormality apart from pallor and bimanually palpable left kidney. Her investigations showed normal renal function and anemia, Computer Topography for Kidney, Ureter, and Bladder (CT-KUB) revealed a large left renal pelvic stone with a hugely enlarged kidney with suspicion of xanthogranulomatous pyelonephritis (XGPN), with almost absent function of the left kidney in DTPA. She underwent Left trans-peritoneal radical nephrectomy. Post-operative histopathology result was moderately differentiated squamous cell carcinoma (T3, N0, M0). To our knowledge this was the first reported case in our hospital, we think that the treatment was fair putting in mind the poor prognosis of the condition and the difficulty in diagnosis.

    Conclusion: This case demonstrates renal pelvis SCC presented with radiological features suggestive of xanthogranulomatous pyelonephritis.

     

     


  • References

    1. [1] Jain A, Mittal D, Jindal A, Solanki R, Khatri S, Parikh A, et al. Incidentally Detected Squamous Cell Carcinoma of Renal Pelvis in Patients with Staghorn Calculi: Case Series with Review of the Literature. ISRN Oncol. 2011; 2011:1–6. https://doi.org/10.5402/2011/620574.

      [2] Geng JH, Chen YT, Juan YS, Huang CH, Chou YH, Wang CJ, et al. Incidentally detected squamous cell carcinoma of the renal pelvis in patients with staghorn calculi - A case report and literature review. Urol Sci. 2013; 24(4):136–9. https://doi.org/10.1016/j.urols.2013.05.004.

      [3] Singh V, Sinha RJ, Sankhwar SN, Mehrotra B, Ahmed N, Mehrotra S. Squamous Cell Carcinoma of the Kidney – Rarity Rede fi ned : Case Series with Review of Literature. 2010; 2(4):82–5.

      [4] Attalla K, Haines K, Labow D, Mehrazin R. Squamous Cell Carcinoma of the Renal Pelvis: Atypical Presentation of a Rare Malignancy. Urol Case Reports [Internet]. 2017; 13:137–9. Available from: https://doi.org/10.1016/j.eucr.2017.04.007.

      [5] Report C. Clinics in Surgery Squamous Cell Carcinoma of the Renal Pelvis Presented as Post-Obstruction Pyonephrosis : A Commonly Known Malignancy in a Rare Location. 2019; 4:4–6.

      [6] Kalayci O, Bozdag Z, Sonmezgoz F, Sahin N. Squamous cell carcinoma of the renal pelvis associated with kidney stones: Radiologic imaging features with gross and histopathological correlation. J Clin Imaging Sci. 2013; 3(1):1–4. https://doi.org/10.4103/2156-7514.109741.

      [7] Kim JR, Jeong YB, Lee NH, Wang S IL. Squamous cell carcinoma of the renal pelvis presenting as an integumentary neoplasm of the flank: A case report. Med (United States). 2019; 98(36):2–6. https://doi.org/10.1097/MD.0000000000017049.

      [8] Ho CI, Wen YK, Chen ML. Xanthogranulomatous pyelonephritis successfully treated with antibiotics only. J Chinese Med Assoc. 2008; 71(12):643–5. https://doi.org/10.1016/S1726-4901(09)70008-5.

      [9] Ramos LD, De M, Lima M, De Carvalho M, Bezerra G, Júnior S, et al. Emphysematous and xanthogranulomatous pyelonephritis: rare diagnosis. Vol. 14, Braz J Infect Dis. 2010. https://doi.org/10.1590/S1413-86702010000400011.

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    Abdalla Ali Alzubier, M., Eltyeb Ibrahim, A., & Mahjoub Taha, S. (2020). Squamous cell carcinoma (SCC) of the renal pelvis following chronic nephrolithiasis; presented with feature suggesting xanthogranulomatous pyelonephritis. International Journal of Medicine, 9(1), 7-9. https://doi.org/10.14419/ijm.v9i1.31239