Preparation and Labeling of Thienopyrimidine and Environmental Remediation of by-products
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Abstract
Thienopyrimidine was prepared using dehydrative cyclisation of phenylisothiocyanate with 4-aminopent-3-en-2-one (enaminone) in presence of dry acetone and Raioiodinated was performed using Chloramine–T and hydrogen peroxide methods as oxidizing agents. The conditions of radioiodination such as concentration of oxidizing agent, reaction time, concentration of thienopyrimidine and effect of pH were studied to get maximum yield. The optimum conditions for radioiodinations using chloramine–T method were 10µg Thienopyrimidine, 12 µg chloramine –T and 1 minute reaction time at pH 7.4. The optimum conditions for radioiodination using hydrogen peroxide method were 10µg Thienopyrimidine, 10 µl hydrogen peroxide: acetic acid (1: 1) and 5 minutes reaction time at pH 7.4. In all cases, the by-products were removed using activated carbon to prevent the environmental threats.
References
[1] Hunter, W.M. and Greenwood, F.C., Labelling of hormones. Nature, 194,495 (1962).
[2] Lednicer, D. and Mitscher, L.A., The organic chemistry of drug synthesis; pergamon press; NY, 1980; Vol. 2, p. 79;
[3] Lednicer, D.; Mitscher, L.A., The organic chemistry of drug synthesis; pergamon press; NY, Vol. 3, p. 152 (1980).
[4] Gad H. M. H., El-Mouhty N. R. A., and Aly H. F., Applicability of Activated Carbon to Treatment of Waste Containing Iodine-Labeled Compounds. Separation Science and Technology, 44: 681–711, 2009.
[5] Carlson, A.A., Nicol, L., Young,A.T., Parlow, A.F. and McNeilly, A.S.,General and comparative Endocrinology ,130,148-156 (2003).
View more references (17)
[6] Demers, L.M., In: Titez fundamentals of clinical chemistry , Burtis,C.A.and Ashwood ,E.R. (Eds),5th ed., Philadelphia , WB Saunders Co.,p.822(2001).
[7] Edwards , R., Immuonoasasay of clinical chemistry , W.M.Hunter and J.E.T.Crrie (Eds) , 2nd ed., Churchill Livingstone, Edinburgh ,p.139(1983).
[8] Edwards, R., Lalloz, M. and Pull,P.I. In: immunoassay for clinical chemistry , W.M.Hunter and J.E.T.Corrie (Eds). 2nd ed., Churchill Livingstone, Edinburgh, p.277 (1983).
[9] El-Kolaly,M.T.., Mehany, N.L.,Ayyoub,S.M. and Hassan, S.E.M., Arab J.Nucl. Sci.Appli.,38(3),241 (2005).
[10] Braschi, I., S. Blasioli, et al., 2009. Removal of sulfonamide antibiotics from water: evidence of adsorption into an organophilic zeolite Y by its structural modifications. J. Hazardous Materials.
[11] Andreozzi, R., M. Canterino, et al., 2005. Antibiotic removal from wastewaters: The ozonation of amoxicillin. J. Hazardous Materials, 123: 243-250.
[12] Urase, T. and T. Kikuta, 2005. Separate estimation of adsorption and degradation of pharmaceutical substances and estrogens in the activated sludge process. Water Res., 39(7): 1289-1300.
[13] Yu, T.H., A.Y.C. Lin, et al., 2009. Removal of antibiotics and non-steroidal anti-inflammatory drugs by extended sludge age biological process. Chemosphere, 77(2): 175-181.
[14] Kunin, R., S. Vetrano, et al., 1990. A novel approach to the use of ion exchange and adsorption media for the processing of pharmaceutical and biological substances. Reactive Polymers, 13(3): 291-298.
[15] Carlesi Jara, C., D. Fino, et al.. 2007. Electrochemical removal of antibiotics from wastewaters. Applied Catalysis B: Environmental, 70(1-4): 479-487.
[16] Kosutic, K., D. Dolar, et al., 2007. Removal of antibiotics from a model wastewater by RO/NF membranes. Separation and Purification Technol., 53(3): 244-249.
[17] Choi, K.J., S.G. Kim, et al., 2008. Removal of antibiotics by coagulation and granular activated carbon filtration. J. Hazardous Materials, 151(1): 38-43.
[18] Yu, Z., S. Peldszus, et al., 2008. Adsorption characteristics of selected pharmaceuticals and an endocrine disrupting compound--Naproxen, carbamazepine and nonylphenol--on activated carbon. Water Res., 42(12): 2873-2882.
[19] Redding, A.M., F.S. Cannon, et al., 2009. A QSAR-like analysis of the adsorption of endocrine disrupting compounds, pharmaceuticals and personal care products on modified activated carbons. Water Res., 43(15): 3849-3861.
[20] Niu, H., Y. Cai, et al., 2007. Evaluation of carbon nanotubes as a solid-phase extraction adsorbent for the extraction of cephalosporins antibiotics, sulfonamides and phenolic compounds from aqueous solution. Analytica Chimica acta, 594(1): 81-92.
[21] Fang, G.Z., J.X. He, et al., 2006. Multiwalled carbon nanotubes as sorbent for on-line coupling of solid-phase extraction to high-performance liquid chromatography for simultaneous determination of 10 sulfonamides in eggs and pork. J. Chromatography A 1127(1-2): 12-17.
[22] Maryam J., Seyed F. A. and Gholamreza K., 2011. Batch Adsorption of Cephalosporins Antibiotics from Aqueous Solution by Means of Multi-Walled Carbon Nanotubes World Applied Sciences Journal 14 (11): 1642-1650.