Impact of Malaria Vaccination on Malaria Infection inCôte d’Ivoire: Mathematical Modeling of MalariaCases‎ in The Context of Childhood Vaccination

  • Authors

    • Mohamed Coulibaly Institut de Recherches Mathématiques, Université Félix Houphouët-Boigny, ‎Abidjan, Côte d’Ivoire https://orcid.org/0000-0003-4431-6544
    • Gerard Kanga Institut de Recherches Mathématiques, Université Félix Houphouët-Boigny, ‎Abidjan, Côte d’Ivoire https://orcid.org/0009-0002-2252-1707
    • N’Da N’Guessan Anastase Mian Institut National de Santé Publique, ministère de la Santé, de l’Hygiène Publique et de la Couverture Maladie Universelle, ‎Abidjan, Côte d’Ivoire
    • N’Dri N’Da Anatole Mian Institut National de Santé Publique, ministère de la Santé, de l’Hygiène Publique et de la Couverture Maladie Universelle, ‎Abidjan, Côte d’Ivoire
    https://doi.org/10.14419/zb1mh603

    Received date: October 24, 2025

    Accepted date: December 25, 2025

    Published date: January 2, 2026

  • SIRS-SI Model; Basic Reproduction Rate; Disease-Free Equilibrium; Numerical Simulation; Predictions.
  • Abstract

    In Côte d’Ivoire, a malaria routine vaccination targeting a specific age group of children began in 2024. In this article, we propose a mathematical model of malaria cases by age group that takes this vaccination into account; this model will allow us to study the impact of this vaccination on malaria dynamics in Côte d’Ivoire. We have shown that it is very costly to reach a disease-free equilibrium and have also determined the ‎basic reproduction number for such an equilibrium. However, we have observed that the vaccination coverage rate strongly influences malaria ‎dynamics. Graphical analysis and numerical simulations corroborate these results. This mathematical model allows us to make predictions that will be ‎important for decision-making and planning‎.

  • References

    1. Institut Pasteur (2024), Paludisme, available online: https://www.pasteur.fr/fr/centre-medical/fiches-maladies/paludisme.
    2. World Health Organization (WHO) (2024), Rapport 2024 sur le paludisme dans le monde, available online: https://www.who.int/fr/teams/global- malaria-programme/reports/world-malaria-report-2024.
    3. Gavi, VaccinesWork (2024), Comment la Coˆ te d’Ivoire va-t-elle de´ ployer le vaccin antipaludique ?, available online: https://www.gavi.org/fr/vaccineswork/comment-la-cote-d-ivoire-va-t-elle-deployer-vaccin-antipaludique.
    4. Gavi, VaccinesWork (2024), Quelle est l’efficacite´ des vaccins contre le paludisme ?, available online: https://www.gavi.org/fr/vaccineswork/quelle-est-efficacite-vaccins-contre-paludisme.
    5. Loukou KSP , Toure´ M , Kone´ S & Yapi YG (2024), Malaria incidence and resistance of Anopheles gambiae s.l, the main vector of malaria in Coˆ te d’Ivoire: Correlation and resistance mechanisms in three localities with low and high incidence of malaria, Int. J. Biol. Chem. Sci., 18(2): 541-554, April 2024. https://doi.org/10.4314/ijbcs.v18i2.17.
    6. World Health Organization (WHO) (2024), La vaccination renforce la lutte contre le paludisme en Coˆ te d’Ivoire, available online: https://www.afro.who.int/fr/countries/cote-divoire/news/la-vaccination-renforce-la-lutte-contre-le-paludisme-en-cote-divoire.
    7. Sir Ronald Ross, The Prevention of malaria, (1910), J. Murray. https://doi.org/10.1155/2024/3855146.
    8. Gizaw AK & Deressa CT (2024), Analysis of Age-Structured Mathematical Model of Malaria Transmission Dynamics via Classical and ABC Fractional Operators, Mathematical Problems in Engineering, 2024, 3855146, 24 pages, (2024).
    9. Duve P, Charles S, Munyakazi J, Lu¨ hken R & Witbooi P (2024), A mathematical model for malaria disease dynamics with vaccination and infect-ed immigrants, Mathematical Biosciences and Engineering, 2024, 21(1): 1082-1109https://doi.org/10.3934/mbe.2024045.
    10. Girol B, Dynamical systems, Invariance Conditions and Applications, FernUniversita¨t in Hagen, Fakulta¨t fu¨ r Mathematik und Informatik, Lehrgebiet Analysis, (2020) , Master Thesis Course, March 22, 2020.
    11. Wiggins S, Introduction to Applied Nonlinear Dynamical Systems and Chaos, Springer, (2003), Volume 2.
    12. Van Den Driessche P & Watmough J (2020), Reproduction numbers and subthreshold endemic equilibria for compartmental models of disease transmission, Math. Biosci., (2002), 121-142.
    13. Sallet G, R0 , INRIA et IRD EPICASA09, avril 2010.
    14. Ministe`re du plan et du De´veloppement, Recensement Ge´ne´ral de la Population et de l’Habitat 2021, ANSTAT, (2022), Abidjan, octobre 2022.
    15. Agence Nationale de la Statistique de Coˆ te d’ivoire, Rapports The´matiques, ANSTAT, (2025), Abidjan, 2025, Available at: https://rp2021.anstat.ci/.
    16. Programme National de Lutte contre le Paludisme (PNLP), Le vaccin antipaludique passe a` l’e´ chelle nationale : la Coˆ te d’Ivoire prote` ge pre` s d’un million d’enfants, PNLP, (2025), Abidjan, july 2025, available at: https://www.pnlpcotedivoire.org/.
    17. World Health Organization (WHO), WHO recommends R21/Matrix-M vaccine for malaria prevention in updated advice on immunization., WHO, October 2023, available at: https://www.who.int/news/item/02-10-2023-who-recommends-r21-matrix-m-vaccine-for-malaria-prevention-in-updated-advice-on-immunization.
    18. Programme Nationnal de Lutte contre le Paludisme (PNLP), Le Paludisme en Coˆ te d’Ivoire, PNLP, (2020), Abidjan, avril 2020. Available at: https://www.pnlpcotedivoire.org/paludisme-en-cote-d-ivoire/.
    19. Zahid MH, Van Wyk H, Morrison AC, Coloma J, Lee GO, Cevallos V, Ponce P & Eisenberg JNS, the biting rate of Aedes aegypti and its variability, A systematic review (1970-2022) (2023), PLoS Negl Trop Dis, 2023 Aug 8;17(8):e0010831, https://doi.org/10.1371/journal.pntd.0010831
    20. Aguiar M, Anam V, Blyuss KB, Estadilla CDS, Guerrero BV, Knopoff D, Kooi BW, Srivastav AK, Steindorf V & Stollenwerk N (2022), Mathemati-cal models for dengue fever epidemiology: A 10-year systematic review, Physics of Life Reviews, Volume 40, Pages 65-92. ISSN 1571-0645 (2022). https://doi.org/10.1016/j.plrev.2022.02.001.
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  • How to Cite

    Coulibaly , M., Kanga , G., Mian, . N. N. A., & Mian, N. N. A. (2026). Impact of Malaria Vaccination on Malaria Infection inCôte d’Ivoire: Mathematical Modeling of MalariaCases‎ in The Context of Childhood Vaccination. International Journal of Basic and Applied Sciences, 14(8), 660-666. https://doi.org/10.14419/zb1mh603