Graph Theoretical Analysis of SARS-COV-2 Spike Protein

  • Authors

    • Akhil C K Department of Mathematics, University College, Thiruvananthapuram, Kerala, India
    • Athul T B Department of Mathematics, Sree Narayana College, Punalur, Kollam, Kerala, India
    • Roy John Department of Mathematics, St.Stephen's College, Pathanapuram, Kollam, Kerala, India
    • Manju N. V Department of Mathematics, University of Kerala, Thiruvananthapuram, Kerala, India
    • Subha A B Department of General Science, Government Engineering College, Bartonhill, Thiruvananthapuram, Kerala, India
    https://doi.org/10.14419/01r2zb80

    Received date: June 23, 2025

    Accepted date: August 3, 2025

    Published date: August 8, 2025

  • Amino acid, SARS-CoV-2 spike protein, Graph, Pt-graph, biological networks

  • Abstract

    The spike protein of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the main surface antigen of the coronavirus. The global pandemic that affected most countries and territories in 2019 was caused by the emergence of the SARS-CoV-2 spike protein. Graph theoretical analysis plays an important role in biological networks. First, we construct the Pt-graph of SARS-CoV-2 based on the physicochemical properties and adjacency of amino acids in the corresponding peptide/protein in SARS-CoV-2. By analyzing the of Pt-graph, we receive some observations about the relations among the amino acids, physiochemical properties of amino acids and peptide/protein, and it will help in the development of and drug design. In this study, we analyze the Pt-graph of the SARS-CoV-2 spike protein to examine its structural properties.

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  • How to Cite

    K, A. C. ., B, A. T. ., John, R. ., V, M. N. ., & B, S. A. . (2025). Graph Theoretical Analysis of SARS-COV-2 Spike Protein. International Journal of Basic and Applied Sciences, 14(4), 194-198. https://doi.org/10.14419/01r2zb80