Plant-Based Bioactive Compounds for Combating Antibiotic ‎Resistance

  • Authors

    • Ashmeet Kaur Chitkara Centre for Research and Development, Chitkara University, Himachal Pradesh, India
    • Shashikant Deepak Assistant Professor, uGDX, ATLAS SkillTech University, Mumbai, India
    • Dr. Pratap Kumar Sahu Professor, Department of Pharmacology, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), ‎Bhubaneswar, Odisha, India
    • Dr. D. Roselin Jenifer Assistant Professor, Department of Bioinformatics, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, India
    • Dr. Shweta Bajaj Professor and Dean, School of Pharmaceutical Sciences, Maharishi University of Information Technology, Uttar Pradesh, India
    • Ankit Sachdeva Centre of Research Impact and Outcome, Chitkara University, Rajpura, Punjab, India
    • Dr. R. Hannah Jessie Rani Assistant Professor, Department of Electrical and Electronics Engineering, Faculty of Engineering and Technology, JAIN (Deemed-to-be ‎University), Ramnagar District, Karnataka, India
    https://doi.org/10.14419/3d542379

    Received date: May 2, 2025

    Accepted date: May 31, 2025

    Published date: November 1, 2025

  • Antibiotics; Lactamases; Overlapping; Development; Bacterial

  • Abstract

    Current antibiotic resistance is one of the most enduring dangers to rigorous antimicrobial stewardship. Even while medications that ‎target bacterial viability have historically delivered outstanding results, the selection pressure that different modes of action exert on the ‎bacteria leads to the production of antibiotic-resistant strains. Finding new antibiotics has been the main focus of most research and exciting ‎advancements, but the gap between the growing number of bacteria that are resistant to drugs and the decreasing number of novel medicines ‎has not yet been closed. Additionally, P. aeruginosa infections are difficult to treat because it can produce new resistance mechanisms to several antibiotic families, including aminoglycosides, fluoroquinolones, and βlactams. As one of the primary causes of nosocomial ‎infections, Pseudomonas aeruginosa can occasionally produce a serious situation in medical facilities. The pathogen can avoid the effects of ‎contemporary antibiotics thanks to its protective outer membrane and efflux pumps, which serve as essential survival tools. As a result, the ‎World Health Organization has designated P. aeruginosa as a priority pathogen because of the growing number of multidrug-resistant ‎‎(MDR) strains that urgently need new medications‎.

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  • How to Cite

    Kaur, A. ., Deepak , S. ., Sahu , D. P. K. ., Jenifer , D. D. R. ., Bajaj , D. S. ., Sachdeva , A. ., & Rani , D. R. H. J. . (2025). Plant-Based Bioactive Compounds for Combating Antibiotic ‎Resistance. International Journal of Basic and Applied Sciences, 14(SI-1), 442-446. https://doi.org/10.14419/3d542379