The Role of Gut Microbiota in Human Health: Implications for ‎Disease Prevention

  • Authors

    • Dr. Satish Upadhyay Assistant Professor, uGDX, ATLAS SkillTech University, Mumbai, India
    • Dr. Laxmidhar Maharana Professor, Department of Pharmacology, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), ‎Bhubaneswar, Odisha, India
    • G. Nancy Priscilla Assistant Professor, Department of Nursing, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, India
    • Anchal Gupta Center of Research Impact and Outcome, Chitkara University, Rajpura, Punjab, India
    • Monika Joshi Assistant Professor, School of Pharmaceutical Sciences, Maharishi University of Information Technology, Lucknow, India
    • H. D. Raghavendra Prasad Assistant Professor, Department of Civil Engineering, Faculty of Engineering and Technology, JAIN (Deemed-to-be University), ‎Ramnagar District, Karnataka, India
    • Bharat Bhushan Chitkara Center for Research and Development, Chitkara University, Himachal Pradesh, India
    https://doi.org/10.14419/hjy03g93

    Received date: May 2, 2025

    Accepted date: May 31, 2025

    Published date: November 1, 2025

  • Gut Microbiota; Diseases; Prevention

  • Abstract

    The host's metabolic health depends on the gut, which is home to trillions of microorganisms, because a healthy gut commensal microbiota ‎is linked to vital processes like digestion, xenobiotic degradation, energy harvesting from food components, water-soluble vitamin ‎production, and metabolite production. It has also been shown that these vital processes can support and improve the intestinal barrier's ‎integrity, the gut epithelium's functional ability, and the body's defense against harmful organisms. Dysbiosis, a disturbance in the ‎equilibrium of the host microbiota brought on by antibiotic usage, menopause, toxins, stress, and gut inflammation, is the cause of disorders ‎like heart disease, autoimmune diseases, autism, obesity, and type 2 diabetes. The expression of the junction protein was down-regulated as a ‎result of changes in intestinal microbial members and food patterns, which raised gut permeability at the epithelial layers. However, while ‎metformin tackles important metabolic abnormalities in type 2 diabetes, recent evidence underscores the necessity of treating the gut ‎microbiota to enhance glucose homeostasis. Bile acid (BA) metabolism, which is essential for controlling glucose, is one of the many ‎aspects of host metabolism that are significantly impacted by the gut microbiota‎.

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  • How to Cite

    Upadhyay, D. S. ., Maharana , D. L. ., Priscilla , G. N. ., Gupta , A. ., Joshi , M. ., Prasad , H. D. R. ., & Bhushan , B. . (2025). The Role of Gut Microbiota in Human Health: Implications for ‎Disease Prevention. International Journal of Basic and Applied Sciences, 14(SI-1), 437-441. https://doi.org/10.14419/hjy03g93