Sensitivity and specificity of CRP as a parameter of atherosclerosis in patients with type II diabetes mellitus

Authors

  • Doaa Mizar Fayoum University, Egypt
  • Hoda Hussein Najran University, KSA Fayoum University, Egypt
  • Mohammad Mashaheet Fayoum University
  • Maher Elamir Fayoum University

DOI:

https://doi.org/10.14419/ijbas.v3i3.3022

Abstract

Background: Type 2 diabetes mellitus (T2DM) is an inflammatory atherosclerotic condition with high prevalence of cardiovascular disease. Elevated C-reactive protein (CRP) predicts cardiovascular events in T2DM patients.

Objectives: Our work aimed to assess sensitivity and specificity of CRP in diagnosis and follow up of carotid atherosclerosis in T2DM patients (detected by measuring carotid intima-media thickness CIMT).

Design and setting: It is observational cross sectional study on T2DM patients from outpatient clinic of fayoum university hospital.

Subjects and methods: Hundred patients with T2DM were included; Group I: statin un-treated, Group II: statin treated, and fifty healthy control persons. Laboratory measurement of total cholesterol, LDL, HDL, and serum CRP levels and carotid duplex scanning were done.

Results: The patients had higher levels of CRP and CIMT than control. There was strong correlation between CIMT and CRP level among group I and II. LDL in diagnosis of atherosclerosis disease illustrated sensitivity (80%) and specificity (4%), while HDL sensitivity (96%) and specificity (36%). CRP showed higher sensitivity (98%) and higher specificity (72%).

Conclusion: CRP level was an important parameter of atherosclerosis with good sensitivity and specificity regardless the level of LDL and HDL.

 

Keywords: Carotid Intima Media Thickness, C Reactive Protein, Type 2 Diabetes Mellitus.

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2014-08-11

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