Primary bone tumours in Kashmir valley a retrospective histopathological study
Keywords:Benign Bone Tumours, Chondrosarcoma, Hematoxyli, Immunohistochemistry, Osteosarcoma, Soft Tissue Sarcoma.
The present study was carried out in the postgraduate department of Pathology at Government Medical College, Srinagar, India, to study the histopathological pattern of primary bone tumors in Kashmir valley over a period of 15 years. During this study, 373 histologically proven primary bone tumors were analyzed. Out of these, 298 were benign (79.89%) and 75 were malignant (20.10%). Peak incidence was in the second and third decade of life with male predominance. Among the malignant tumors, the highest incidence was that of Osteosarcoma (52%), followed by Ewingâ€™s sarcoma (24%) and Chondrosarcoma (14%). Osteochondroma (49%) was the most frequent tumor in the benign category. The most commonly affected bones were femur, tibia and humerus in that order. Comparison with similar studies from other parts of the globe indicate that the relative frequency of primary bone tumors appears to be low but shows a rising trend in the last 10 years in this part of the world.
 Yeole B. B, Jussawalla D. J Descriptive epidemiology of bone cancer in greater Bombay.Indian J Cancer. 1998 Sep; 35(3):101-6.
 Katchy K. C, Zaid F, Alexander S, Gad H, Abder M. M Malignant bone tumors in Kuwait, a 10 year clinicopathological study. International Orthopaedics 2005; 29: 406-411. http://dx.doi.org/10.1007/s00264-005-0014-6.
 Dorfman H. D, Czerniak B Bone cancers.Cancer. 1995 Jan 1; 75(1 Suppl):203-10. http://dx.doi.org/10.1002/1097-0142(19950101)75:1+<203::AID-CNCR2820751308>3.0.CO;2-V.
 Polednak A. P (1985) Primary bone cancer incidence in black and white residents of New York State. Cancer 55: 2883-2888.
 Sissons H. A Population studies on bone tumours. Proc R Soc Med. Jun 1971; 64(6): 643â€“644.
 Dodge O. G Bone tumours in Uganda Africans.Br J Cancer 18(4): 627-633, 1964 http://dx.doi.org/10.1038/bjc.1964.72.
 Azra S, Jan G. M Pattern of cancer at Srinagar (Kashmir). Indian Jour Pathol Microbiol; 33:2; 118-23, 1990.
 Mattoo A. R, Kaul H. K Incidence of malignant neoplasms in Kashmir Jour of Indian Med Ass Vol. 69(9):309-311.1974.
 Sarma N. H , Al Fituri O, Visweswara R. N, Saeed S. O Primary bone tumour in eastern Libya--a 10 year study.Cent Afr J Med. Jun;40(6):148-51, 1994
 Rao V. S, Pai M. R, Rao R. C, Adhikary M. M Incidence of primary bone tumors and tumor like lesions in and around Dakshina Kannada district of Karnataka. J Indian Med Asssoc, 1996 March 94(3); 103-4,121.
 Christenson P. C Bone tumors- analysis of one thousand cases with special reference to location, age and sex. Annals of Surgery, 81:1074-92, 1925. http://dx.doi.org/10.1097/00000658-192506010-00004.
 Larsson S. E, Lorentzon R The geographic variation of the incidence of malignant primary, bone tumors in Sweden. Journal of Bone and Joint Surgery 56A:592-600, 1974.
 Parkin D. M, Stiller C. A, Nectoux J International variations in the incidence of childhood bone tumours. Int J Cancer. 1993 Feb 1; 53(3):371-6. http://dx.doi.org/10.1002/ijc.2910530305.
 Rosenberg A Robbins pathologic basis of disease 6th edition, 1234, 1999
 Uribe-Botero G, Russell W. O, Sutow W. W, Martin R. G Primary osteosarcoma of bone. Clinicopathologic investigation of 243 cases, with necropsy studies in 54. American Journal of Clinical Pathology 1977, 67(5):427-435
 Springfield D. S, Capanna R, Gherlinzoni F, Picci P, Campanacci M Chondroblastoma, a review of seventy cases.J Bone Joint Surg Am. 1985 Jun;67(5):748-55.
 Fain J. S, Unni K. K, Beabout J. W, Rock MG. Nonepiphyseal giant cell tumor of the long bones. Clinical, radiologic, and pathologic study. Cancer. 1993 Jun 1; 71(11):3514-9. http://dx.doi.org/10.1002/1097-0142(19930601)71:11<3514::AID-CNCR2820711109>3.0.CO;2-A.
 Sung H. W, Kuo D. P, Shu W. P, Chai Y. B, Liu C. C, Li S. M Giant-cell tumor of bone: analysis of two hundred and eight cases in Chinese patients. J Bone Joint Surg Am, 1982 Jun; 64(5):755-761.
 Dorfman H. D, Czerniak Bogdan Bone tumours 1012-1013 1998.