Alterations of 8-iso-prostaglandin F2 alpha levels in heart failure patients with preserved ‎and reduced ejection fraction- a case-control study

  • Authors

    • Jasmine Chandra A PhD scholar, Department of Biochemistry, Sri Ramachandra Institute of Higher Education and ‎Research, Porur, Chennai, Tamil Nadu, India 600116 https://orcid.org/0000-0001-5224-5534
    • Sowmiya T Ph D Scholar, Department of Biochemistry, Sri Ramachandra Institute of Higher Education and ‎Research, Porur, Chennai, India 600116 https://orcid.org/0000-0001-8908-9432
    • Karthikeyan Rajamani Senior Scientist, Department of Public Health, Sri Ramachandra Institute of Higher Education ‎and Research, Porur, Chennai, Tamil Nadu, India https://orcid.org/0000-0001-6533-6689
    • Santhi Silambanan Professor of Biochemistry, Sri Ramachandra Institute of Higher Education and Research, ‎Porur, Chennai, Tamil Nadu, India, 600116
    https://doi.org/10.14419/04d9k841

    Received date: March 31, 2025

    Accepted date: May 7, 2025

    Published date: May 10, 2025

  • Biomarkers; Cardiology; Heart Failure; Oxidative Stress; Stroke Volume

  • Abstract

    Introduction: ‎Heart failure (HF) poses a global health challenge with decreased quality of life. HF can be HF ‎with reduced ejection fraction (HFrEF) or preserved ejection fraction (HFpEF). Oxidative ‎stress is implicated in the pathophysiology of heart failure. The study aimed to find the ‎association of the oxidative biomarker 8-iso-prostaglandin F2 Alpha (8-iso-PGF2α) with the ‎severity of heart failure. ‎

    Methods:‎ The case-control study was conducted in the Departments of Cardiology and Biochemistry at ‎Sri Ramachandra Institute of Higher Education and Research, India. The study involved 80 HF ‎patients (HFpEF: n=40, HFrEF: n=40) aged between 30 and 75 years of both genders. ‎Enzyme-Linked Immunosorbent Assay analyzed 8-iso-PGF2α. Institutional ethics committee ‎approval was obtained. Statistical analysis was performed using SPSS software version 16. P ≤ ‎‎0.05 was considered statistically significant.‎

    Results:‎ HFpEF was more prevalent in the 46-60 age group, whereas HFrEF was more common in the ‎‎61-75 age group. Among HFpEF and HFrEF, 8-iso-PGF2  levels were 910.07 ± 286.97 and ‎‎1185.02 ± 396.75 (p=0.001). 8-iso-PGF2 showed correlation with NT-proBNP and ‎echocardiography.‎

    Conclusions: ‎Elevated 8-iso-PGF2α levels suggested a potential link between oxidative stress and heart ‎failure severity, contributing to our understanding of oxidative stress in heart failure

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    A, J. C., T, S., Rajamani, K. ., & Silambanan, S. (2025). Alterations of 8-iso-prostaglandin F2 alpha levels in heart failure patients with preserved ‎and reduced ejection fraction- a case-control study. International Journal of Basic and Applied Sciences, 14(1), 228-235. https://doi.org/10.14419/04d9k841