Design and analysis of MEMS based capacitive pressure sensor for the detection of colon cancer

  • Abstract
  • Keywords
  • References
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  • Abstract

    Emerging sciences have brought tremendous changes in the electronic world. One such revolutionary technology is MEMS. MEMS extend their implementation into many sectors like mechanical sensors, micro fluids, medical implants, bio-MEMS. In this paper, we discuss the design of a Micro Bio-sensor which senses the capacitance fluctuations materialized in it by various reactions of antigen and antibody. It is a cantilever based structure which is coated with a drug that is responsive to Carcino Embryonic Antigen (CEA), which is considered to be a first level indicator of colon cancer present in human body. The presence of this disease causing element in the blood initiates the antibody-antigen interactions which induces changes in the electrical parameters of the sensor device. These changes are utilized to determine the severity level of pathogens present in the patient’s blood.

  • Keywords

    Bio-MEMS, Capacitance, Cantilever, CEA, antibody-antigen reaction, Deflection of cantilever, Capacitance.

  • References

      [1] D. Klaitabtim and A. Tuantranont, "Design consideration and finite element modeling of MEMS cantilever for nano-biosensor applications," Procs. of 2005 5th IEEE Conference on Nanotechnology, Nagoya, Japan, July 2005

      [2] V. Jain, S. Verma, "Design and analysis of MEMS piezoresistive three layers microcantilever-based sensor for biosensing applications," International Journal of Innovative Technology and Exploring Engineering, Volume-2, Issue-5, April 2013.

      [3] P. G. Gopinath, V. R. Anitha, S. Aruna Mastani, "Microcantilever based biosensor for disease detection applications," Journal of Medical and Bioengineering, Vol. 4, No.4, August 2015.

      [4] Y. Lu, V. Chivukula, M. Wang and H. F. Ji, "Simulation and fabrication of Si02-based piezoresistive microbridges for chemlbiosensors," J Micromech. Microeng, vol. 16,692-698,2006.

      [5] S. Dhakane, W. V. Patil, "Piezo-resistive method for tuberculosis detection using microcantilever biosensor," Microsyst Technol, 2013.

      [6] B. Bais, R. A. Rahim and B. Y. Majlis, "Finite element and system level analyses of piezoresistive microcantilever for biosensing

      [7] Applications", Australian Journal of Basic and Applied Sciences, vol.5, No.l2, pp. 1038-1046,2011.

      [8] Srinivasa Rao K, Sateesh Jasti, “Design and Analysis of MEMS based Bio sensor for TB detection, ICEECCOT, 2016.

      [9] Dr. Seetaiah Kilaru, Hari Kishore K, Sravani T, Anvesh Chowdary L, Balaji T “Review and Analysis of Promising Technologies with Respect to fifth Generation Networks”, 2014 First International Conference on Networks & Soft Computing, ISSN:978-1-4799-3486-7/14,pp.270-273,August2014.

      [10] Meka Bharadwaj, Hari Kishore "Enhanced Launch-Off-Capture Testing Using BIST Designs” Journal of Engineering and Applied Sciences, ISSN No: 1816-949X, Vol No.12, Issue No.3, page: 636-643, April 2017.

      [11] N Bala Dastagiri, Kakarla Hari Kishore "Reduction of Kickback Noise in Latched Comparators for Cardiac IMDs” Indian Journal of Science and Technology, ISSN No: 0974-6846, Vol No.9, Issue No.43, Page: 1-6, November 2016.

      [12] A Murali, K Hari Kishore, D Venkat Reddy "Integrating FPGAs with Trigger Circuitry Core System Insertions for Observability in Debugging Process” Journal of Engineering and Applied Sciences, ISSN No: 1816-949X, Vol No.11, Issue No.12, page: 2643-2650, December 2016.

      [13] Mahesh Mudavath, K Hari Kishore "Design of CMOS RF Front-End of Low Noise Amplifier for LTE System Applications Integrating FPGAs” Asian Journal of Information Technology, ISSN No: 1682-3915, Vol No.15, Issue No.20, page: 4040-4047, December 2016.

      [14] P Bala Gopal, K Hari Kishore, B.Praveen Kittu “An FPGA Implementation of On Chip UART Testing with BIST Techniques”, International Journal of Applied Engineering Research, ISSN 0973-4562, Volume 10, Number 14 , pp. 34047-34051, August 2015.

      [15] S Nazeer Hussain, K Hari Kishore "Computational Optimization of Placement and Routing using Genetic Algorithm” Indian Journal of Science and Technology, ISSN No: 0974-6846, Vol No.9, Issue No.47, page: 1-4, December 2016.

      [16] N Bala Gopal, K Hari Kishore "Analysis of Low Power Low Kickback Noise in Dynamic Comparators in Pacemakers” Indian Journal of Science and Technology, ISSN No: 0974-6846, Vol No.9, Issue No.44, page: 1-4, November 2016.

      [17] S.V.Manikanthan and K.Baskaran “Low Cost VLSI Design Implementation of Sorting Network for ACSFD in Wireless Sensor Network”, CiiT International Journal of Programmable Device Circuits and Systems,Print: ISSN 0974 – 973X & Online: ISSN 0974 – 9624, Issue : November 2011, PDCS112011008.

      [18] Rajesh, M., and J. M. Gnanasekar. "GCCover Heterogeneous Wireless Ad hoc Networks."Journal of Chemical and Pharmaceutical Sciences (2015): 195-200.

      [19] T.Padmapriya, Ms. N. Dhivya, Ms U. Udhayamathi, “Minimizing Communication Cost In Wireless Sensor Networks To Avoid Packet Retransmission”, International Innovative Research Journal of Engineering and Technology, Vol. 2, Special Issue, pp. 38-42.




Article ID: 9126
DOI: 10.14419/ijet.v7i1.5.9126

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