Non- invasive technique using breath analysis for detection and classification of diabetes

  • Authors

    • Lekha Srinivasan Vellore Institute of Technology, Chennai Campus
    • Suchetha M. Associate Professore, Vellore Institute of Technology, Chennai Campus
    2015-08-24
    https://doi.org/10.14419/ijet.v4i3.4898
  • Acetone Concentration, Breath, Blood Glucose Level, Diabetes, Supports Vector Classifier.
  • Diabetes, a metabolic disease that is characterized by high glucose level in the blood, is a major problem affecting millions of people today. This disease if left unchecked can create enormous implication on the health of the population. Among the various non-invasive methods of detection, breath analysis presents an easier, more accurate and viable method in providing comprehensive clinical care for the disease. This paper examines the concentration of acetone levels in breath for monitoring blood-glucose levels and thus predicting diabetes. The analysis uses the support vector mechanism to classify the response to healthy and diabetic samples. For the analysis, ten subject samples of acetone levels are taken into consideration and are classified according to three labels, which are healthy, type one diabetic and type two diabetic.

  • References

    1. [1] Prashanth Makaram, Dawn Owens and Juan Aceros, Trends in Nanomaterial-Based Non-Invasive Diabetes Sensing Technologies, Diagnostics 2014.

      [2] Wolfram Miekisch, Jochen K Schubert, Gabriele F.E Noeldge-Schomburg, Diagnostic potential of breath analysis—Focus on volatile organic compounds, Clinica Chimica Acta 2004. http://dx.doi.org/10.1016/j.cccn.2004.04.023.

      [3] Kim DG Van de Kant, Linda J.T.M van der Sande, Quirijn Jöbsis, Onno C.P van Schayck, Edward Dompeling, Clinical use of exhaled volatile organic compounds in pulmonary diseases: a systematic review, Respiratory Research 2012.

      [4] Tassopoulos, C.N., Barnett, D, Fraser, T.R, Breath-acetone and blood-sugar measurements in diabetes, Lancet 1969. http://dx.doi.org/10.1016/S0140-6736(69)92222-3.

      [5] Chunhui Deng, Jie Zhang, Xiaofeng Yu, Wei Zhang and Xiangmin Zhang, Determination of acetone in human breath by gas chromatography–mass spectrometry and solid-phase microextraction with on-fiber derivatization, Journal of Chromatography 2004. http://dx.doi.org/10.1016/j.chroma.2004.10.005.

      [6] Moorhead, D. Lee, J. G. Chase, A. Moot, K. Ledingham, J. Scotter, R. Allardyce, S. Senthilmohan, and Z. Endre, Classification Algorithms for SIFT-MS medical diagonosis, Proceedings of the 29th Annual International Conference of the IEEE EMBS Cité Internationale, Lyon, France August 23-26, 2007.

      [7] Chuji Wang, Armstrong Mbi and Mark Shepherd, a Study on Breath Acetone in Diabetic Patients Using a Cavity Ringdown Breath Analyzer: Exploring Correlations of Breath Acetone with Blood Glucose and Glycohemoglobin A1C, IEEE Sensors Journal, Vol. 10, NO. 1, January 2010. http://dx.doi.org/10.1109/JSEN.2009.2035730.

      [8] P. Wang, Y. Tan, H. Xie, and F. Shen, A novel method for diabetes diagnosis based on electronic nose, Biosensors and Bioelectronics, Vol. 12, No. 9, pp. 1031–1036, 1997.

      [9] D. Guo, D. Zhang, N. Li, L. Zhang, and J. Yang, A novel breath analysis system based on electronic olfaction, IEEE Transaction on Biomedical Engineering, Vol. 57, No. 11, November 2010.

      [10] P. Wang, Y. Tan, H. Xie, and F. Shen, A novel method for diabetes diagnosis based on electronic nose, Biosensors and Bioelectronics, Vol. 12, No. 9, pp. 1031–1036, 1997.

      [11] C.Wang,A.Mbi,andM.Shepherd, A study on breath acetone in diabetic patients using a cavity ringdown breath analyzer: Exploring correlations of breath acetone with blood glucose and glycohemoglobin a1c, IEEE Sens. J., vol. 10, no. 1, pp. 54–63, Jan. 2010. http://dx.doi.org/10.1109/JSEN.2009.2035730.

      [12] C. Turner, C. Walton, S. Hoashi, and M. Evans, Breath acetone concentration decreases with blood glucose concentration in type I diabetes mellitus patients during hypoglycaemic clamps, J. Breath Res., vol. 3, no. 4, p. 046004, Dec. 2009. http://dx.doi.org/10.1088/1752-7155/3/4/046004.

      [13] C. Deng, J. Zhang, X. Yu, W. Zhang, and X. Zhang, Determination of acetone in human breath by gas chromatography-mass spectrometry and solid-phase microextraction with on-ï¬ber derivatization, J. Chromatogr. B, vol. 810, no. 2, pp. 269–275, 2004. http://dx.doi.org/10.1016/S1570-0232(04)00657-9.

      [14] C.-C. Chang and C.-J. Lin, LIBSVM: A library for support vector machines, ACM Trans. Intell. Syst. Technol., vol. 2, no. 3, 27, pp. 1–27, 2011.

      [15] C. J. Burges, A tutorial on support vector machines for pattern recognition, Data Mining Knowl. Discovery, vol. 2, no. 2, pp. 121–167, 1998. http://dx.doi.org/10.1023/A:1009715923555.

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  • How to Cite

    Srinivasan, L., & M., S. (2015). Non- invasive technique using breath analysis for detection and classification of diabetes. International Journal of Engineering & Technology, 4(3), 460-464. https://doi.org/10.14419/ijet.v4i3.4898