Heavy metal concentrations in the blood and the risk of allergic diseases for South Korean children and adolescents

 
 
 
  • Abstract
  • Keywords
  • References
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  • Abstract


    The purpose of this study was to investigate the effects of heavy metal concentration in the blood on allergic diseases in Korean children and adolescents using the Korean National Health and Nutrition Examination Survey (KNHANES) data. For the study, a secondary analysis of the data collected via the sixth KNHNES in the first year (2013) was conducted. The study subjects were 1,065 children. All the data were analyzed through a two-sided test at a significance level α=.05 using SPSS 24. As a result, the geometric mean concentrations of lead, mercury and cadmium in the blood were 1.25±0.03 ㎍/dL, 1.95±0.08 ㎍/L and 0.35±0.03 ㎍/L. As for allergic diseases, 6.2% of the children were diagnosed by doctors with asthma, 17.7% with atopic dermatitis, and 24.7% with allergic rhinitis. When mercury concentration in the blood increased by 0.1 ㎍/L, the possibility of allergic rhinitis prevalence was significantly increased by 1.31 times (p=.040). The above results indicate that heavy metal concentration in the blood of children affects allergic diseases. Therefore, in the future, an analytic epidemiological study should be conducted to investigate allergic diseases and related factors considering the characteristics of each heavy metal.

     


  • Keywords


    Atopic Dermatitis, Allergic Rhinitis, Asthma, Health Surveys, Heavy Metal

  • References


      [1] YonhapNews (2018), A serious fine dust, available online: http://www.yonhapnews.co.kr/bulletin/2018/01/21/0200000000AKR20180121025400033.HTML?input=1195m, last visit:1.5.2018.

      [2] Ailshire JA & Clarke P (2015), Fine particulate matter air pollution and cognitive function among U.S. older adults. The Journals of Gerontology Series B: Psychological Sciences and Social Sciences 70(2), 322-328.

      [3] Ministry of Environment (2016), What is it about fine dust, available online: http://www.me.go.kr/ebook/svs/gt/view/159, last visit:1.5.2018.

      [4] NIH (National Institute of Environmental Health Sciences) (2018), Lead, available online: https://www.niehs.nih.gov/health/topics/agents/lead/, last visit:1.5.2018.

      [5] KCDC (Korea Centers for Disease Control and Prevention) (2016), Heavy metals in daily life: lead, available online: http://health.cdc.go.kr/health/HealthInfoArea/HealthInfo/View.do?idx=14210, last visit:1.5.2018.

      [6] Falck AJ, Mooney S, Kapoor SS, White KM, Bearer C & Metwally D (2015), Developmental exposure to environmental toxicants. Pediatric Clinics of North America 62(5), 1173-1197.

      [7] Edelman C, Mandle CL & Kudzma EC (2014), Health Promotion Throughout the Life Span, 8th edn. Amsterdam: Elsevier, pp.415-503.

      [8] Hsueh YM, Lee CY, Chien SN, Chen WJ, Shiue HS, Huang SR, Lin MI, Mu SC &. Hsieh RL (2017), Association of blood heavy metals with developmental delays and health status in children. Scientific Reports 7(43608), 1-9.

      [9] NIH (National Institute of Environmental Health Sciences) (2018), Asthma, available online: https://www.niehs.nih.gov/health/topics/conditions/asthma/, last visit:2.5.2018.

      [10] Wang S & Zhang J (2006), Blood lead levels in children. China. Environmental Research 101(3), 412-418.

      [11] Sears CG & Zierold KM (2017), Health of children living near coal ash. Global Pediatric Health 4, 1-8.

      [12] Miyake Y, Tanaka K, Yasutake A, Sasaki S & Hirota Y (2011), Lack of association of mercury with risk of wheeze and eczema in Japanese children: the Osaka maternal and child health study. Environmental Research 111(8), 1180-1184.

      [13] Lee YH, Choi JH, Park MR, Kim JH, Kim WK, Park YM, Lee SY, Han MY, Chae YM, Ham MI, Lee KJ, Kwon HJ & Ahn KM (2015), Analysis of regional prevalence of allergic diseases in Korean school children. Allergy Asthma & Respiratory Disease 3(1), 62-69.

      [14] Nutten S (2015), Atopic dermatitis: global epidemiology and risk factors. Annals of Nutrition and Metabolism 66(1), 8-16.

      [15] Shin JY, Kim JM & Kim YR (2012), The association of heavy metals in blood, fish consumption frequency, and risk of cardiovascular diseases among Korean adults: the Korean National Health and Nutrition Examination Survey (2008-2010). The Korean Journal of Nutrition 45(4), 347-361.

      [16] Kim JY, Shin MS, Kim SH, Seo JH, Ma HS & Yang YJ (2017), Association of iron status and food intake with blood heavy metal concentrations in Korean adolescent girls and women: based on the 2010~2011 Korea National Health and Nutrition Examination Survey. Journal of Nutrition and Health 50(4), 350-360.

      [17] Chung SE & Cheong HK, The correlation of blood metal concentration and daily nutrition intake amount in Korea (2011), Proceedings of the 2011 Annual Conference of Korean Society of Environmental Toxicology, 10(1), 228-229.

      [18] Choi IS & Choi SC (2014), Contents and migration of heavy metals and phthalates in children`s products and phthalates in children`s products. Journal of Korean Society of Environmental Engineers 36(2), 127-138.

      [19] Vrijheid M, Casas M, Gascon M, Valvi D & Nieuwenhuijsen M (2016), Environmental pollutants and child health - a review of recent concerns. International Journal of Hygiene and Environmental Health 219(4), 331-342.

      [20] Kim JH, Jeong KS, Ha EH, Park H, Ha MN, Hong YC, Lee SJ, Lee KY, Jeong JS & Kim YH (2013), Association between prenatal exposure to cadmium and atopic dermatitis in infancy. Journal of Korean Medical Science 28(4), 516-521.

      [21] KCDC (Korea Centers for Disease Control and Prevention) (2013), The Sixth Korea national health and nutrition examination survey (KNHANES Ⅵ).

      [22] CDC (Centers for Disease Control and Prevention) (2018), National report on human exposure to environmental chemicals, available online: https://www.cdc.gov/exposurereport/, last visit:2.5.2018.

      [23] Schulz C, Wilhelm M, Heudorf U & Kolossa-Gehring M (2011), Update of the reference and HBM values derived by the German human biomonitoring commission. International Journal of Hygiene and Environmental Health 215(1), 26-35.

      [24] Ministry of the Interior and Safety (2014), Environmental exposure and health survey in children and adolescents, available online: http://www.prism.go.kr/homepage/entire/retrieveEntireDetail.do?pageIndex=1&research_id=1480000-201400091&leftMenuLevel=160&cond_research_name=%EA%B1%B4%EA%B0%95%EC%8B%A4%ED%83%9C&cond_research_start_date=&cond_research_end_date=&pageUnit=10&cond_order=3, last visit:1.5.2018.

      [25] CHMS (Canadian Health Measures Survey) (2010), Table 10: final human health state of the science report on lead, available online: https://www.canada.ca/en/health-canada/services/environmental-workplace-health/reports-publications/environmental-contaminants/table-10-blood-lead-levels-blls-canada-united-states-canadian-adults-children.html, last visit:1.5.2018.

      [26] Ku IY, Kim HS, Lee JP, Song KS & Kim YK (2015), Pb, Hg and Cd concentration of blood and exposure related factors. Journal of Korea Academia-Industrial Cooperation Society 16(3), 2089-2099.

      [27] Kim YA, Kim YN, Cho KD, Kim MY, Kim EJ, Baek OH & Lee BH (2011), Blood heavy metal concentrations of Korean adults by seafood consumption frequency: using the fourth Korea national health and nutrition examination survey (KNHANES IV), 2008. The Korean Journal of Nutrition 44(6), 518-526.

      [28] Lando AM & Zhang Y (2011), Awareness and knowledge of methylmercury in fish in the United States. Environmental Research 111(3), 442-450.

      [29] Lee JY, Lee MJ, Leem JH, Lamichhane DK, Hong YC, Kim YH, Ha MN & Ha EH (2016), Green spaces and allergic outcomes in children, Proceeding of the 2016 Annual Conference of Korean Society of Environmental Toxicology, 6(1), 96.

      [30] Hong SY, Kwon HJ, Choi WJ, Lim WR, Kim JH & Kim KS (2014), Association between exposure to antimicrobial household products and allergic symptoms. Environmental Health and Toxicology 29, 120-125.

      [31] Choi HS, Ahn HY & Woo JJ (2018), Effects of blood heavy metal concentration in school children on allergic disease. International Journal of Bio-Science and Bio-Technology 10(2), 7-12.


 

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Article ID: 25464
 
DOI: 10.14419/ijet.v8i1.4.25464




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