Effect of light pulse width on frequency characteristics of photoacoustic signal – an experimental study using a pulse-width tunable LED-based photoacoustic imaging system

  • Authors

    • Toshitaka Agano Osaka University
    • Mithun Kuniyil Ajith Singh CYBERDYNE Inc
    • Ryo Nagaoka Toyama University
    • Kunio Awazu Osaka University
  • Frequency Response, LED, Photoacoustic Imaging, Pulse Width, Ultrasound Imaging.
  • Photoacoustic imaging is a hybrid technique that bridges the depth limits of ballistic optical imaging and the resolution limits of diffuse optical imaging. Using the acoustic waves generated in response to the absorption of pulsed light, it provides noninvasive high-resolution images of optical absorption at depths of several centimeters. This promising technique with optical contrast and ultrasonic resolution has shown potential in wide range of clinical and preclinical applications. In this work, we experimentally study the influence of light pulse width on frequency characteristics of photoacoustic signal, using an LED-based photoacoustic imaging system. We acquired photoacoustic image of the flat surface of a pencil lead at different excitation light pulse widths and the resulting frequency response of the photoacoustic temporal signal is compared with the product of Fourier transform of the light pulse and the frequency response of the ultrasound detector. Our results give a confirmation that frequency characteristics of photoacoustic signal is directly dependent on the combined response of light pulse frequencies and the frequency bandwidth of the ultrasound probe. Also, our results show that it is critical to tune pulse width of excitation light based on ultrasound probe’s frequency response, for efficient data acquisition in multiscale photoacoustic imaging.



  • References

    1. [1] Y. Zhou, J. Yao, and L. V. Wang, "Tutorial on photoacoustic tomography," Journal of biomedical optics, Vol 21, No 6, (2016), 61007. https://doi.org/10.1117/1.JBO.21.6.061007.

      [2] S. Manohar, and D. Razansky, “Photoacoustics: a historical review, “Advances in Optics and Photonics, Vol 8, No 4, (2016), pp. 586-617. https://doi.org/10.1364/AOP.8.000586.

      [3] M. Kuniyil Ajith Singh, W. Steenbergen, and S. Manohar, "Handheld Probe-Based Dual Mode Ultrasound/Photoacoustics for Biomedical Imaging," in Frontiers in Biophotonics for Translational Medicine M. Olivo, and U. S. Dinish, Eds., Springer Singapore (2016), pp. 209-247.

      [4] K. Irisawa, T. Hirasawa, K. Hirota et al, "Influence of laser pulse width to the photoacoustic temporal waveform and the image resolution with a solid-state excitation laser," Proc. SPIE 8223, Photons plus Ultrasound: Imaging and Sensing (2012), 82232W.

      [5] A. Hariri, J. Lemaster, J. Wang et al, “The characterization of an economic and portable LED-based photoacoustic imaging system to facilitate molecular imaging,†Photoacoustics, Vol 9 (2018), pp. 10-20. https://doi.org/10.1016/j.pacs.2017.11.001.

      [6] W. Xia, M. Kuniyil Ajith Singh, E. Maneas et al, “Handheld Real-Time LED-Based Photoacoustic and Ultrasound Imaging System for Accurate Visualization of Clinical Metal Needles and Superficial Vasculature to Guide Minimally Invasive Procedures,†Sensors, Vol 18, No 5, (2018), 1394. https://doi.org/10.3390/s18051394.

      [7] Y. Zhu, G. Xu, J. Yuan et al, “Light Emitting Diodes based Photoacoustic Imaging and Potential Clinical Applications,†Nature Scientific Reports, Vol 8, (2018), 9885. https://doi.org/10.1038/s41598-018-28131-4.

      [8] T. Agano, N. Sato, H. Nakatsuka et al, "High frame rate photoacoustic imaging using multiple wave-length LED array light source," Proc. SPIE 9708 Photons Plus Ultrasound: Imaging and Sensing, (2016), 97084E.

      [9] W. Xia, D. Piras, M. Kuniyil Ajith Singh et al, “Design and evaluation of a laboratory prototype system for 3D photoacoustic full breast tomography,†Biomedical optics express, Vol 4, No 11, (2013), pp. 2555-2569. https://doi.org/10.1364/BOE.4.002555.

      [10] P. Beard, “Biomedical photoacoustic imaging,†Interface Focus Vol 1, No 4 (2011), pp. 602–631. https://doi.org/10.1098/rsfs.2011.0028.

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  • How to Cite

    Agano, T., Kuniyil Ajith Singh, M., Nagaoka, R., & Awazu, K. (2018). Effect of light pulse width on frequency characteristics of photoacoustic signal – an experimental study using a pulse-width tunable LED-based photoacoustic imaging system. International Journal of Engineering & Technology, 7(4), 4300-4303. https://doi.org/10.14419/ijet.v7i4.19907