Preparation of a monolithic sorbent using a response surface methodology

  • Authors

    • Xiaoxia Li Inha University
    • Yu Ri Lee Inha University
    • Kyung Ho Row Inha University
    https://doi.org/10.14419/ijet.v5i2.5769

    Received date: January 17, 2016

    Accepted date: May 24, 2016

    Published date: May 27, 2016

  • Preparation, Monomer, Crosslinkerer, Porogen, Response Surface Methodology.

  • Abstract

    A 17-run Box-Behnken Design (BBD) was introduced to optimize the synthesis conditions of a monolithic sorbent. The effects of the amount of monomer (mL), crosslinker (mL) and porogen (mL) were investigated. The experimental data was fitted to a second - order polynomial equation by multiple regression analysis, which was examined using statistical methods. The adjusted coefficient of determination (R2Adj) in this model was 0.9867. The probability value (p<0.0001) revealed the high significance of the regression model. A mean amount of 5057.4 mg polymer was produced under the following optimized synthesis conditions: 0.51 mL monomer, 2.94 mL crosslinker and 2.84 mL porogen. The actual experimental result was in good agreement with the predicted model value.

  • References

    1. Fontanals N., Marce R.M. and Borrull F, New materials in sorptive extraction techniques for polar compounds. Journal of Chromatog-raphy A, 1152 (2007) 14-31. http://dx.doi.org/10.1016/j.chroma.2006.11.077.
    2. Guerrouache M., Carbonnier B., Vidal-Madjar C. and Millot M.C, In situ functionalization of N-acryloxysuccinimide-based monolith for reversed-phase electrochromatography. Journal of Chromatog-raphy A, 1149 (2007) 368-376. http://dx.doi.org/10.1016/j.chroma.2007.03.039.
    3. Luo Q., Zou H., Xiao X., Guo Z., Kong L. and Mao X, Chromato-graphic separation of proteins on metal immobilized iminodiacetic acid-bound molded monolithic rods of macroporous poly (glycidyl methacrylate–co-ethylene dimethacrylate). Journal of Chromatog-raphy A, 926 (2001) 255-264. http://dx.doi.org/10.1016/S0021-9673(01)01055-X.
    4. Tanaka N., Kobayashi H., Ishizuka N., Minakuchi H., Nakanishi K., Hosoya K. and Ikegami T, Monolithic silica columns for high-efficiency chromatographic separations. Journal of Chromatography A, 965 (2002) 35-49. http://dio:10.1016/S0021-9673(01)01582-5.
    5. Hashem H. and Jira T, Chromatographic Applications on Monolithic Columns: Determination of Triamcinolone, Prednisolone and Dex-amethasone in Pharmaceutical Tablet Formulations Using a Solid Phase Extraction and a Monolithic Column. Chromatographia, 61 (2005) 133-136. http://10.1365/s10337-004-0479-2.
    6. Körner A. and Kohn S, Development and optimization of a stability indicating method on a monolithic reversed-phase column for Col-chicum dry extract. Journal of Chromatography A, 1089 (2005) 148-157. http://doi:10.1016/j.coroma.2005.06.084.
    7. Mihelič I., Nemec D., Podgornik A. and Koloini T, Pressure drop in CIM disk monolithic columns. Journal of Chromatography A, 1065 (2005) 59-67. http://doi.10.1016/j.chroma.2004.10.054.
    8. Zhu T. and Row K.H, Extraction and Determination of Cefazolin Sodium and Cefotaxime Sodium in Human Urine with a Weak Ion Exchange Monolithic Column. Journal of Liquid Chromatography &Related Technologies, 32 (2009) 1423-1433. http://dx.doi.org/10.1080/10826070902900954.
    9. Zhu T. and Row K.H, Extraction and Determination of β-Sitosterol from Salicornia herbacea L. Using Monolithic Cartridge. Chroma-tographia, 71 (2010) 981-985. http://10.1365/s10337-010-1574-1.
    10. Carballo J. L., Naranjo S., Kukurtzü B., Calle F. D. L. and Hernán-dez-Zanuy A. Production of Ecteinascidia turbinata (Ascidiacea: Perophoridae) for Obtaining Anticancer Compounds. Journal of the World Aquaculture Society, 31 (2000) 481-490. http://dx.doi.org/10.1111/j.1749-7345.2000.tb00900.x.
    11. Cacace J. E. and Mazza G. Optimization of Extraction of Anthocy-anins from Black Currants with Aqueous Ethanol. Journal of Food Science, 68 (2003) 240-248. http://dx.doi.org/10.1111/j.1365-2621.2003.tb14146.x.
    12. Wu Y., Cui S.W., Tang J. and Gu X. Optimization of extraction process of crude polysaccharides from boat-fruited sterculia seeds by response surface methodology. Food Chemistry, 105 (2007) 1599-1605. http://dx.doi.org/10.1016/j.foodchem.2007.03.066.
    13. Han D., Tian M. and Row K. H. Isolation of Four Compounds from Herba Artemisiae Scopariae by Preparative Column HPLC Journal of Liquid Chromatography &Related Technologies, 32 (2009) 2407-2416. http://dx.doi.org/10.1080/10826070903188120.
    14. Zhu T., Heo H.J. and Row K.H. Optimization of crude polysaccha-rides extraction from Hizikia fusiformis using response surface methodology. Carbohydrate Polymer, 82 (2010) 106-110. http://dx.doi.org/10.1016/j.carbpol.2010.04.029.
    15. Box G. E. P. and Behnken D.W. Some New Three Level Designs for the Study of Quantitative Variables. Technometrics, 2 (1960) 455-475. http://dx.doi.org/10.1080/00401706.1960.10489912.
    16. Ferreira S.L.C., Bruns R.E., Ferreira H.S., Matos G.D., David J.M., Brandão G.C., da Silva E. G. P., Portugal L. A., dos Reis P. S., Sou-za A. S. and dos Santos W. N. L. Box-Behnken design: An alterna-tive for the optimization of analytical methods. Analytica Chimica Acta, 597 (2007) 179-186. http://dx.doi.org/10.1016/j.aca.2007.07.011.
    17. Tian M., Zhu T., Park H.E. and Row K.H. Purification of 4-hydroxybenzoic Acid and 4-hydroxybenzaldehyde from Laminaria japonica Aresch Using Commercial and Monolithic Sorbent in SPE Cartridge. Analytical Letters, 45 (2012) 2359-2366. http://dx.doi.org/10.1080/00032719.2012.691590.
    18. Xu H., Sun L. P., Shi Y. Z., Wu Y. H., Zhang B. and Zhao D.Q. Optimization of cultivation conditions for extracellular polysaccha-ride and mycelium biomass by Morchella esculenta As51620. Bio-chemical Engineering Journal, 39 (2008) 66-73. http://dx.doi.org/10.1016/j.bej.2007.08.013.
    19. Li R., Chen W., Wang W., Tian W. and Zhang X. Optimization of extraction technology of Astragalus polysaccharides by response surface methodology and its effect on CD40. Carbohydrate Poly-mers, 78 (2009) 784-788. http://dx.doi.org/10.1016/j.carbpol.2009.06.018.

  • Downloads

    Additional Files

  • How to Cite

    Li, X., Lee, Y. R., & Row, K. H. (2016). Preparation of a monolithic sorbent using a response surface methodology. International Journal of Engineering and Technology, 5(2), 47-50. https://doi.org/10.14419/ijet.v5i2.5769