Skip to content
IJET International Journal of Engineering and Technology E-ISSN 2227-524X

Synthesis and Spectral Studies of Novel Palladium (O) Complex with Ciprofloxacin Antibiotic

Abstract

New complex of Palladium (0) with ciprofloxacin has been synthesized, The complex was portrayed by different physico - substance systems like essential examination, m.pt. , TLC, molar conductance estimation, attractive helplessness,13C- NMR, 1H-NMR and FT-IR. According to the results obtained, tetrahedral structure suggested for the prepared complex. The neutral ligand act in a Didentate mode, binding through oxygen atom of carbonyl group in pyridonering and oxygen atom of carboxyl ate group.

Authors and Affiliations

  • N. S. Majeed
  • I. K. Kareem
  • N. N.A. Jafar

About this article

Download PDF

Keywords

  • Spectral studies
  • palladium complex
  • ciprofloxacin
  • elemental analysis.

References

[1] Mertindale W, Martindale – the extra Pharmacopeia, 30thed, the Pharmaceutical Press, London, (1993).

[2] Turel I, Golobič A, Klavžar A, Pihlar B, Buglyo P, Tolis E & Sepčić K, “Interactions of oxovanadium (IV) and the quinolone family member—ciprofloxacin”, Journal of inorganic biochemistry, Vol.95, No.2, (2003), pp.199-207.

[3] Serafin A & Staczak A, “Russian Journal of Coordination Chemistry”, Springer, Vol.35, No.2, (2009), pp.83-97.

[4] Anacona JR & Toledo C, “Synthesis and antibacterial activity of metal complexes of ciprofloxacin”, Transition Metal Chemistry, Vol.26, No.1-2, (2001), pp.228-231.

[5] Psomas G, “Mononuclear metal complexes with ciprofloxacin: synthesis, characterization and DNA-binding properties”, Journal of inorganic biochemistry, Vol.102, No.9, (2008), pp1798-1811.

View more references (15)

[6] Delaney S, Pascaly M, Bhattacharya PK, Han K & Barton JK, “Oxidative damage by ruthenium complexes containing the dipyridophenazine ligand or its derivatives: a focus on intercalation”, Inorganic chemistry, Vol.41, No.7, (2002), pp.1966-1974.

[7] Kara M, Hasinoff BB, McKay DW & Campbell NR, “Clinical and chemical interactions between iron preparations and ciprofloxacin”, British journal of clinical pharmacology, Vol.31, No.3, (1991), pp.257-261.

[8] Ball P, “Quinolone generations: natural history or natural selection?”, Journal of Antimicrobial Chemotherapy, Vol.46, No.3, (2000), pp.17-24.

[9] Turel I, “The Interactions of metal ions with quinolone Antibacterial Agents”, Coordination Chemistry Reviews, Vol.232, No.1-2, (2002), pp.27-47.

[10] Vieira LMM, De Almeida MV, De Abreu HA, Duarte HA, Grazul RM & Fontes APS, “Platinum (II) complexes with fluoroquinolones: Synthesis and characterization of unusual metal–piperazine chelates”, Inorganica Chimica Acta, Vol.362, No.6, (2009), pp.2060-2064.

[11] Rusu A, Tóth G, Szőcs L, Kökösi J, Kraszni M, Gyéresi Á & Noszál B, “Triprotic site-specific acid–base equilibria and related properties of fluoroquinolone antibacterials”, Journal of pharmaceutical and biomedical analysis, Vol.66, (2012), pp.50-57.

[12] Siddiqi ZA, Khalid M, Kumar S, Shahid M & Noor S, “Antimicrobial and SOD activities of novel transition metal complexes of pyridine-2, 6-dicarboxylic acid containing 4-picoline as auxiliary ligand”, European journal of medicinal chemistry, Vol.45, No.1, (2010), pp.264-269.

[13] Liu YC, Chen ZF, Shi SM, Luo HS, Zhong DC, Zou HL & Liang H, “Synthesis, crystal structure of polyoxovanadate complex of ciprofloxacin: V4O10(μ2-O)2 [VO(H-Ciprof)2]2·13H2O by hydrothermal reaction”, Inorganic Chemistry Communications, Vol.10, No.11, (2007), pp.1269-1272.

[14] Negishi E, Handbook of Organ palladium Chemistry for Organic Synthesis, Wiley-Inter science: New York, (2002).

[15] Tsuji J, Palladium in Organic Synthesis, Springer: Berlin, (2005).

[16] Li J & Gribble GW, Palladium in Heterocyclic Chemistry, Pergamon: New York, (2000).

[17] Jafar NN & Majeed NS, “Microwave-assisted synthesis and biological activity of ester, carbothioate and carbohydrazide derivative compounds of the drug Ciprofloxacin”, J. Chem. Pharmaceut. Sci., Vol.10, (2017), pp.515-521.

[18] Nakamoto K, Infrared spectra of inorganic and coordination compounds. 2nded. New York: Wiley Inter science, (1970).

[19] Ferraro JR, Low frequency vibrations of inorganic and coordination compounds. 2nded. New York: John Wiley, (1971).

[20] Kothari R, Sharma B, Sahawal S, Neha K, Mandal S, Birthare S & Shivhare V, “Synthesis, Characterization And Antimicrobial Evaluation of Copper (Ii) Complex with Ciprofloxacin Antibiotic”, World Journal of Pharmacy and Pharmaceutical Sciences, Vol.4, No.6, (2015), pp.696-707.


How to Cite

S. Majeed, N., K. Kareem, I., & N.A. Jafar, N. (2018). Synthesis and Spectral Studies of Novel Palladium (O) Complex with Ciprofloxacin Antibiotic. International Journal of Engineering and Technology, 7(4.36), 722-724. https://doi.org/10.14419/ijet.v7i4.36.24230