Synthesis of Nitrogen-Containing Chalcone Via One-Pot Three-Component Reaction . part ii

  • Authors

    • Mustafa Abualreish Dept.of chem Faculty of science Northern Border University
    • Anwar E. M. Nor E. Ljaleel
    • Himat M. A. Fadul
    • Saad M. H. Ayuob
    • M. Abdel Karim
    • Jan H. Van Der Westhuizen Van Der Westhuizen
  • Chalcone, 3-Hydroxybenzaldehyde, 4-Methoxyacetophenone, Aminomethylation, Formaldehyde, N-Methylpiperazine.
  • The compound 3-Hydroxy-4'-methoxychalcone (1) was prepared by reacting 3-hydroxybenzaldehyde with 4-methoxyacetophenone.

    The aminomethylation of this chalcone was accomplished by reaction with formaldehyde and N-methylpiperazine in dry acetonitrile to Obtain 3-hydroxy-4'-methoxy-4-(N-methyl-piperazinomethyl) chalcone (2) and 3-hydroxy-4'-methoxy-2,4-bis-(N-methylpiperazinomethyl)chalcone(3). The products were purified by column and thin layer chromatography and were identified along with their intermediates by spectroscopic methods: UV, IR, NMR and mass spectrometry.

  • References

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    Abualreish, M., Ljaleel, A. E. M. N. E., Fadul, H. M. A., Ayuob, S. M. H., Abdel Karim, M., & Van Der Westhuizen, J. H. V. D. W. (2014). Synthesis of Nitrogen-Containing Chalcone Via One-Pot Three-Component Reaction . part ii. International Journal of Advanced Chemistry, 3(1), 1-5.