Study of ternary association of anti-microbial drug 1, 10-phenanthroline and α - amino acid with copper salt, an ultrasonic investigation of competitive interaction

  • Abstract
  • Keywords
  • References
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  • Abstract

    Molecular interaction studies using ultrasonic technique and spectroscopic investigation in ternary liquid mixture of drug 1,10-Phenanthroline, an α- amino acid Glycine and a transition metal salt like CuCl2 in aqueous medium has been carried out at 300.15K and 2 MHz frequency. Using experimental values of density (ρ),ultrasonic velocity (U) and UV analysis, different acoustical parameters such as adiabatic compressibility (β),intermolecular free length (Lf), acoustic impedance (z),relative association (RA),apparent molar volume (V), apparent molar adiabatic compressibility (K) are evaluated for the mixture of drug, glycine and inorganic salt CuCl2 at various concentrations. The ultrasonic and spectroscopic investigation clearly shows coordinative association of drug as a ligand with transition metal salt. Further interaction of glycine as an α- amino acid indicates a competitive association in the ternary system. The outcomes were expressed in terms of molecular interactions and the variation in parameters under varying solute concentrations providing conclusive remarks regarding the strength of intermolecular interactions in the ternary system with a bio-physical novelty.


  • Keywords

    1,10-Phenanthroline; α - Amino Acid; Adiabatic Compressibility; Acoustic Impedance; Apparent Molar Volume; Relative Association.

  • References

      [1] Kumar H &Behal I (2016) Densities and Speeds of Sound of Antibiotic Drug Chloramphenicol with l-Leucine and Glycyl-l-leucine in Aqueous Medium at T = (288.15–318.15) K: A Volumetric, Ultrasonic, and UV Absorption Study. J. Chem. Eng. Data 61, 3740−3751.

      [2] Iqbal MJ & Chaudhry MA (2009) Thermodynamic study of three pharmacologically significant drugs: Density, viscosity, and refractive index measurements at different temperatures. J. Chem. Thermodynamics 41,221–226.

      [3] Bencini A &Lippolis V (2010) 1, 10-Phenanthroline: A versatile building block for the construction of ligands for various purposes. Coordination Chemistry Reviews 254, 2096–2180.

      [4] Nalle PB, Birajdar SD, Shinde BR, Dorik RG & Jadhav KM (2016) Effect of drug Piper nigrum on physicochemical properties of zinc chloride at varying concentration and temperature investigated through ultrasonic tool. Cogent Chemistry 2,1216721

      [5] Abebe A, Atlabachew M, Liyew M &Ferede E (2018) Synthesis of N-Tetradecyl-1,10-phenathrolinium -Based New Salts for Biological Applications. Hindawi Bioinorganic Chemistry and Applications 4, ID 8097483.

      [6] Cardozo E, Vielma JE, Fontal B, Contreras RR, Reyes M, Bellandi F, Fonseca Y & Romero V(2015) Synthesis, characterization and hydrogenation catalysis in biphasic medium (organic/water) of samarium(III) complex with glycine and 2,2-bipyridine ligands. AvancesenQuímica 10 & 21-24.

      [7] Berger AJ, Dieudonne S & Ascher P (1998) Glycine Uptake Governs Glycine Site Occupancy at NMDA Receptors of Excitatory Synapses. J Neurophysiol 80(6), 3336-3340.

      [8] Aragon C &Corcuera BL (2005) Glycine transporters: crucial roles of pharmacological interest revealed by gene deletion. Trends Pharmacol Sci. 26(6), 283-286.

      [9] Arredondo M & Nunez MT (2005) Iron and copper metabolism. Molecular Aspects of Medicine 26, 313–327.

      [10] Chohan ZH, Arif M, Akhtar MA &Supuran CT (2006) Metal-Based Antibacterial and Antifungal Agents: Synthesis, Characterization, and In Vitro Biological Evaluation of Co(II), Cu(II), Ni(II), and Zn(II) Complexes with Amino Acid-Derived Compounds. Bioinorganic Chemistry and Applications 2006, ID 83131.

      [11] Venkatramana L, Narasimha Rao C, Sivakumar K &Gardas RL (2015) Volumetric, acoustic and FT-IR spectroscopic study on ternary and constituent binary mixtures containing N-methylcyclohexylamine, nitrobenzene and 1-alkanols at 303.15 K. Journal of Molecular Liquids 209, 578–585.

      [12] Rajagopal K &Jayabalakrishnan SS (2010) Volumetric, ultrasonic speed, and viscometric studies of salbutamol sulphate in aqueous methanol solution at different temperatures. J. Chem. Thermodynamics 42, 984–993.

      [13] Syal VK, Thakur SK, Chauhan S & Sharma P (2005) Ultrasonic Velocity Studies of Drug Parvon-spas in Mixed Alcohol–Water Solvent Systems at 25°C. International Journal of Thermophysics 26 (3).

      [14] Sonar AN, Pawar NS &Khairnar MD (2011) Ultrasonic studies on molecular interaction of substitute heterocyclic compounds in acetone-water mixture at 303K. International Journal of Applied Biology and Pharmaceutical Technology 2(3), 291-295.

      [15] Tadkalkar A, Pawar P &Bichile GK (2011) Studies of acoustic and thermodynamic properties of citric acid in double distilled water. J.Chem. Pharm.Res. 3(3), 165.

      [16] Eyring H &Kincaud JF (1938) free volumes and free angle ratios of molecules in liquids. The Journal of Chemical Physics 6(10), 620-629.

      [17] Naik RR, Bawankar SV, Tekade PV &Mahodaya Om A (2015) Ultrasonic study of pyridoxine solutions at different temperatures and concentrations. Russian Journal of Physical Chemistry 89(1), 152–158.

      [18] Naik RR, Bawankar SV &Ghodki VM (2015) Acoustical Studies of Molecular Interactions in the Solution of Anti-Malarial Drug. Journal of Polymer and Biopolymer Physics Chemistry 3 (1), 1-5.

      [19] Abdelkarim AT, Al-Shomrani MM, Rayan AM & El-Sherif AA (2015) Mixed Ligand Complex Formation of Cetirizine Drug with Bivalent Transition Metal(II) Ions in the Presence of 2-Aminomethylbenzimidazole: Synthesis, Structural, Biological, pH-Metric and Thermodynamic Studies, J Solution Chem. 44,1673-1704

      [20] Khan F, Rub MA, Azum N, Kumar D &Asiri AM (2015) Interaction of an Amphiphilic Drug and Sodium Bis (2-ethylhexyl) sulfosuccinate at Low Concentrations in the Absence and Presence of Sodium Chloride, J Solution Chem. 44,1937–1961.

      [21] Gaba R, Pal A, Sharma D & Sharma K (2016) Solvation behavior of glycine and diglycine in aqueous 1-butyl-3-methylimidazolium chloride ionic liquid solutions at different temperatures, Journal of Molecular Liquids 220, 954–960.

      [22] Banik I & Roy MN (2012) Study of solute–solvent interaction of some bio-active solutes prevailing in aqueous ascorbic acid solution, Journal of Molecular Liquids 169, 8-14.




Article ID: 30541
DOI: 10.14419/ijac.v8i1.30541

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