Synthesis, characterization and antimicrobial activity of Mn(ii) and Zn(ii) complexes with leucine and alanine

  • Authors

    • Hamza Jibrin Okpanaki Okpanaki
    • Dr A. D Onu
    • Prof. S.O. Idris
    2019-09-20
    https://doi.org/10.14419/ijac.v7i1.28944
  • Antimicrobial Activities, Characterization, Molar Conductivity, Synthesis, X-Ray Diffraction.
  • Abstract

    Background: Transition metals are essential metallic element and they exhibit great biological activity. In recent time, researches have shown significant progress in the utilization of transition metal complexes as drugs for treatment of several human disorders like cancer, infections and neurological disorders, amongst others.

    Objective: The study attempted to obtain neutral complexes of MLn.nH2O type (M = Mn/Zn and L = leucine/alanine), characterize, and then study their biological activities.

    Methods: 2mmols of the ligands were dissolved each, in 20 ml distilled water and 0.33 ml of 30% NaOH was added. Then 1 mmol of the metal salts was dissolved in 2 ml of water and stirred, the salt solution was added to the solution of the ligand and stirred. The dark brown and white precipitates for manganese amino acid complex and zinc amino acid complexe respectively were filtered off, washed, dried in air and then weighed to establish the percent of complexation. The complexes were then subjected to both spectroscopic and non-spectroscopic method of analysis.

    Result: The result suggested the coordination of the ligand to the central metal.

    Conclusion: The results suggested monoclinic crystal system for all the complexes formed. The antimicrobial studies showed an enhanced biological sensitivity for the complexes when compared with that of the ligands, and the structure of the newly synthesized complexes were proposed to be octahedral for Mn-amino acid and tetrahedral for the Zn-amino acid.

     

     

     

  • References

    1. [1] Ajil. P., Antony, A., Fasna, F., and Varkey J. (2016). Amino Acid based Schiff Bases and its Zn (II) Complexes. Journal of Chemistry, 5(2)

      [2] Al- Noor, T. H., Fayad, N. K., Mahmood, A. A. and Malih, I. K. (2013). Synthesis, Characterization, and Antibacterial Studies of Mn (II),Fe (II) , Co(II) , Ni(II), Cu (II) and Cd(II) Mixed- Ligand Complexes Containing Amino Acid ( L-Valine) And (1,10-phenanthroline). Chemistry and Materials Research, 3(5), 2224- 3224.

      [3] Annapure, R. S., Munde, S. A. and Rathod, D. S. (2016). Spectral, Thermal, X-Ray and Antimicrobial Studies of Newer Tetradentate N2O2 Schiff Base Complexes of First Transition Series. Der ChemicaSinica, 7 (4):47-54.

      [4] Blyth, K M., Bronswijk, W., Mullings, L. R., Phillips, D. N. nd Pritchard, D. (2005). Preparation, Analysis, and Characterization of Some Transition Metal Complexes-A Holistic Approach. Journal of chemical education, 82(11). www.JCE.DivCHED.org. https://doi.org/10.1021/ed082p1667.

      [5] Chondhekar, K. T., Shankarwar, G. S. Sakhare, T. D. and Shankarwar, G. A. (2015). Synthesis, characterization of some transition metal complexes of bidentate Schiff base and their antifungal and antimicrobial studies. Advances in Applied Science Research, 6(6), 10-16.

      [6] Choudharya A., Sharmaa R. and Nagar M. (2011). Synthesis, characterization and antimicrobial activity of mixed ligand complexes of Co (II) and Cu (II) with N, O/S donor ligands and amino acids. Iternational Research Journal of Pharmacy and Pharmacology, 1(6), 172-187

      [7] Cozma, D., David, L., Marcu, A., Nagy, C., Rusu, D., Stanila, A. (2009). Spectroscopic investigations of new metallic complexes with leucine as ligand. Nuclear Instruments and Methods in Physics Research, 418, www.elsevier.com/locate/nimb.

      [8] Dharwadkar, S. R. Shivankar, V. S., Thakkar N. V. and Vaidya, R. B. (2003). Synthesis, characterization, and biological activity of mixed ligand Co (II) complexes of 8-hydroxyquinoline and some amino acids. Synthesis and reactivity in inorganic and metal-organic chemistry, 33(9), 1597-1622.https://doi.org/10.1081/SIM-120025443.

      [9] Johari, R., Kumar, G. and Singh, S. (2009). Synthesis and antibacterial activity of M (II) Schiff base complex. Journal of Indian Council of Chemistry. 26:23–7.

      [10] Papish, E. T., Taylor, M. T., Jernigan, F. E., Rodig, M. J., Shawhan, R. R., Yap G. P. A. and Jove F. A. (2006). Synthesis of Zinc, Copper, Nickel, Cobalt, and Iron Complexes Using Tris(pyrazolyl)methane Sulfonate Ligands: A Structural Model for N, N, O Binding in Metalloenzymes. Inorganic Chemistry, 45(5), 2242-2250https://doi.org/10.1021/ic051579a.

      [11] Yiase, S. G., Adejo S. O., Gbertyo J. A. and Edeh, J. (2014). Synthesis, Characterization and Antimicrobial Studies of Salicylic Acid Complexes of Some Transition Metals. Journal of Applied Chemistry, 7(4), 4-10.https://doi.org/10.9790/5736-07420405.

  • Downloads

  • How to Cite

    Jibrin Okpanaki, H., A. D Onu, D., & S.O. Idris, P. (2019). Synthesis, characterization and antimicrobial activity of Mn(ii) and Zn(ii) complexes with leucine and alanine. International Journal of Advanced Chemistry, 7(1), 104-111. https://doi.org/10.14419/ijac.v7i1.28944

    Received date: 2019-04-23

    Accepted date: 2019-07-06

    Published date: 2019-09-20