Preparation of a monolithic sorbent using a response surface methodology

 
 
 
  • Abstract
  • Keywords
  • References
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  • Abstract


    A 17-run Box-Behnken Design (BBD) was introduced to optimize the synthesis conditions of a monolithic sorbent. The effects of the amount of monomer (mL), crosslinker (mL) and porogen (mL) were investigated. The experimental data was fitted to a second - order polynomial equation by multiple regression analysis, which was examined using statistical methods. The adjusted coefficient of determination (R2Adj) in this model was 0.9867. The probability value (p<0.0001) revealed the high significance of the regression model. A mean amount of 5057.4 mg polymer was produced under the following optimized synthesis conditions: 0.51 mL monomer, 2.94 mL crosslinker and 2.84 mL porogen. The actual experimental result was in good agreement with the predicted model value.


  • Keywords


    Preparation; Monomer; Crosslinkerer; Porogen; Response Surface Methodology.

  • References


      [1] Fontanals N., Marce R.M. and Borrull F, New materials in sorptive extraction techniques for polar compounds. Journal of Chromatography A, 1152 (2007) 14-31. http://dx.doi.org/10.1016/j.chroma.2006.11.077.

      [2] Guerrouache M., Carbonnier B., Vidal-Madjar C. and Millot M.C, In situ functionalization of N-acryloxysuccinimide-based monolith for reversed-phase electrochromatography. Journal of Chromatography A, 1149 (2007) 368-376. http://dx.doi.org/10.1016/j.chroma.2007.03.039.

      [3] Luo Q., Zou H., Xiao X., Guo Z., Kong L. and Mao X, Chromatographic separation of proteins on metal immobilized iminodiacetic acid-bound molded monolithic rods of macroporous poly (glycidyl methacrylate–co-ethylene dimethacrylate). Journal of Chromatography A, 926 (2001) 255-264. http://dx.doi.org/10.1016/S0021-9673(01)01055-X.

      [4] Tanaka N., Kobayashi H., Ishizuka N., Minakuchi H., Nakanishi K., Hosoya K. and Ikegami T, Monolithic silica columns for high-efficiency chromatographic separations. Journal of Chromatography A, 965 (2002) 35-49. http://dio:10.1016/S0021-9673(01)01582-5.

      [5] Hashem H. and Jira T, Chromatographic Applications on Monolithic Columns: Determination of Triamcinolone, Prednisolone and Dexamethasone in Pharmaceutical Tablet Formulations Using a Solid Phase Extraction and a Monolithic Column. Chromatographia, 61 (2005) 133-136. http://10.1365/s10337-004-0479-2.

      [6] Körner A. and Kohn S, Development and optimization of a stability indicating method on a monolithic reversed-phase column for Colchicum dry extract. Journal of Chromatography A, 1089 (2005) 148-157. http://doi:10.1016/j.coroma.2005.06.084.

      [7] Mihelič I., Nemec D., Podgornik A. and Koloini T, Pressure drop in CIM disk monolithic columns. Journal of Chromatography A, 1065 (2005) 59-67. http://doi.10.1016/j.chroma.2004.10.054.

      [8] Zhu T. and Row K.H, Extraction and Determination of Cefazolin Sodium and Cefotaxime Sodium in Human Urine with a Weak Ion Exchange Monolithic Column. Journal of Liquid Chromatography &Related Technologies, 32 (2009) 1423-1433. http://dx.doi.org/10.1080/10826070902900954.

      [9] Zhu T. and Row K.H, Extraction and Determination of β-Sitosterol from Salicornia herbacea L. Using Monolithic Cartridge. Chromatographia, 71 (2010) 981-985. http://10.1365/s10337-010-1574-1.

      [10] Carballo J. L., Naranjo S., Kukurtzü B., Calle F. D. L. and Hernández-Zanuy A. Production of Ecteinascidia turbinata (Ascidiacea: Perophoridae) for Obtaining Anticancer Compounds. Journal of the World Aquaculture Society, 31 (2000) 481-490. http://dx.doi.org/10.1111/j.1749-7345.2000.tb00900.x.

      [11] Cacace J. E. and Mazza G. Optimization of Extraction of Anthocyanins from Black Currants with Aqueous Ethanol. Journal of Food Science, 68 (2003) 240-248. http://dx.doi.org/10.1111/j.1365-2621.2003.tb14146.x.

      [12] Wu Y., Cui S.W., Tang J. and Gu X. Optimization of extraction process of crude polysaccharides from boat-fruited sterculia seeds by response surface methodology. Food Chemistry, 105 (2007) 1599-1605. http://dx.doi.org/10.1016/j.foodchem.2007.03.066.

      [13] Han D., Tian M. and Row K. H. Isolation of Four Compounds from Herba Artemisiae Scopariae by Preparative Column HPLC Journal of Liquid Chromatography &Related Technologies, 32 (2009) 2407-2416. http://dx.doi.org/10.1080/10826070903188120.

      [14] Zhu T., Heo H.J. and Row K.H. Optimization of crude polysaccharides extraction from Hizikia fusiformis using response surface methodology. Carbohydrate Polymer, 82 (2010) 106-110. http://dx.doi.org/10.1016/j.carbpol.2010.04.029.

      [15] Box G. E. P. and Behnken D.W. Some New Three Level Designs for the Study of Quantitative Variables. Technometrics, 2 (1960) 455-475. http://dx.doi.org/10.1080/00401706.1960.10489912.

      [16] Ferreira S.L.C., Bruns R.E., Ferreira H.S., Matos G.D., David J.M., Brandão G.C., da Silva E. G. P., Portugal L. A., dos Reis P. S., Souza A. S. and dos Santos W. N. L. Box-Behnken design: An alternative for the optimization of analytical methods. Analytica Chimica Acta, 597 (2007) 179-186. http://dx.doi.org/10.1016/j.aca.2007.07.011.

      [17] Tian M., Zhu T., Park H.E. and Row K.H. Purification of 4-hydroxybenzoic Acid and 4-hydroxybenzaldehyde from Laminaria japonica Aresch Using Commercial and Monolithic Sorbent in SPE Cartridge. Analytical Letters, 45 (2012) 2359-2366. http://dx.doi.org/10.1080/00032719.2012.691590.

      [18] Xu H., Sun L. P., Shi Y. Z., Wu Y. H., Zhang B. and Zhao D.Q. Optimization of cultivation conditions for extracellular polysaccharide and mycelium biomass by Morchella esculenta As51620. Biochemical Engineering Journal, 39 (2008) 66-73. http://dx.doi.org/10.1016/j.bej.2007.08.013.

      [19] Li R., Chen W., Wang W., Tian W. and Zhang X. Optimization of extraction technology of Astragalus polysaccharides by response surface methodology and its effect on CD40. Carbohydrate Polymers, 78 (2009) 784-788. http://dx.doi.org/10.1016/j.carbpol.2009.06.018.


 

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Article ID: 5769
 
DOI: 10.14419/ijet.v5i2.5769




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