Pharmacological evaluation of oxazine sulfonamide derivatives for anti-inflammatory, analgesic and antipyretic activities
Abstract
Oxazine heterocyclic compound containing one oxygen and one nitrogen atom. They possess different pharmacological activities like anticancer, anti-ulcer, antifungal, antithrombotic, antihypertensive, analgesic, anti-inflammatory etc. Oxazine Sulphonamide derivatives were investigated for anti-inflammatory, analgesic and anti-pyretic activities. It was evaluated for anti-inflammatory activity by carrageenan induced paw edema in rats using Plethysmometer and it also shows significant analgesic effect in male Albino mice. Antipyretic activity was also investigated.
About this article
Keywords
- Analgesic
- Ant-Pyretic
- Anti-Inflammatory
- Oxazine Sulphonamide Derivatives
- Yeast
- Carrageenan
- Plethysmometer.
References
[1] Albert.Meyers, AikoNabeya, H.WayneAdickes, J. MichealFitzpatrick, G. Ray Malone, and leve R. Politzerpp 1969, Aldehydes from dihydro-1,3-oxazines. II. Synthesis of. Alpha.Beta. -Unsaturated aldehyde and their C-1 deuterated derivatives, J. Am.Chem. Soc 764-767.
[2] Basudeb, A; Sukhendu, M.;Dutta, P.K.; Chowdhury,C. 2004. Synette, 14, 2449.
[3] BencsicsS, Elenkov IJ, Vizi EJ. 1995. Alpha 2-, alpha 2A-, alpha 2B/2C-adrenoceptor subtype antagonist prevent lipopolysaccharide-induced fever response in rabbits. Brain Res; 705:302-306.http://dx.doi.org/10.1016/0006-8993(95)01154-4.
[4] B lettes, E.;Lockhart, B.; Lestage, P.; Schwendimann, L.; Gressens,P.; Fleury,, M-B.; Largeron, M.2005 J. Med. Chem. 48,1282.
[5] Breder CD, Dinarello CA, Saper CB.1988, Interleukin-1 immunoreactive innervations of the human hypothalamus. Science; 240:321-324.http://dx.doi.org/10.1126/science.3258444.
[6] Buckman, B.O; Mohan, R.; KOovakkat,DS.1998, Bioorg. Med. Chem. Lett.,8, 2235.http://dx.doi.org/10.1016/S0960-894X(98)00386-2.
[7] Burke W.J.Am. Chem.Soc 1954;76;1677.http://dx.doi.org/10.1021/ja01635a065.
[8] C.A Winter, E. Risley, and G. Nuss, “Carrageenan-induced edema in hind aw of the rat as an assay for imflmmatory drugs,” Proceedings of the societyfor Experimental Biology and Medicine, vol.111, pp.544-547,1962.http://dx.doi.org/10.3181/00379727-111-27849.
[9] Chiu, H. I.; Lin C.; Cheng, C. Y.; Tsai, M. C.; Yu, H.C. 2001 Bioorg. Med. Chem. Lett., 9, 383.http://dx.doi.org/10.1016/S0968-0896(00)00260-1.
[10] Chiistie, R.M., Agyako, C.K., Mitchel, 1995 Dyes pigments, 29, 241.http://dx.doi.org/10.1016/0143-7208(95)00049-L.
[11] David,M., Aroff, M.D., Eric, G., Neilson, M.D.,2001. Antipyretics: Mechanism of Action and Clinical Use in Fever Supression.
[12] I. Posadas, M. Bucci, F. Roviezzo et al., “Carrageenan-induced mouse paw oedema is biphasic, age-weight fependant and displays differential nitric oxide cuclooxygenase-2 expression,” British journal of pharmacology, vol. 142, no. 2, pp. 331-338, 2004
[13] Jahnke K, thiel E, Bechrakis NE,2008 “ Ifosamide or trofosfamide on patients with intraocular lymphoma”. J. Neurooncol.93 (2): 213-217.http://dx.doi.org/10.1007/s11060-008-9761-8.
[14] Kajino, N.; Shibouta; Nishikawa, K.; Meguro, K. 1991 Chem. Pharm. Bull. 11 2896.http://dx.doi.org/10.1248/cpb.39.2896.
[15] Katsure, Y.; Nishino, S., Takasugi, H. 1991 Chem. Pharm. Bull. 11, 293.
[16] Li S, Ballou LR, Morham SG.2001 Cyclooxygenase-2 mediates the febrile response of mice to interleukin-1 beta. Brain Res; 910:163-173.http://dx.doi.org/10.1016/S0006-8993(01)02707-X.
[17] Li S, Sehic E, Wang Y. 1999 Relationship between complement andthe febrile response of guinea pigs to systemic Endotoxin. Am J Physiol; 277:1635-1645A.
[18] M. Harsh, Inflammation and Healing, Jaypee publication, 2002.
[19] Nair, M.G.; Saltor, O. C.; Kisliuk, R. L.; Gaumont, Y. 1983, J. Med Chem. 26 1164. http://dx.doi.org/10.1021/jm00362a015.
[20] Organic synthesis, Coll Vol. 6, p.905 (1988): Vol. 51, p.24 (1971).
[21] Rawlins, M., 1973. Mechanism of salicylate –induced antpyresis. S Karger AG, 311.
[22] ShaliniDalal, MD, and Donna S. Zhukovsky, MD, FACP2006. Pathophysiology of Fever.
[23] Sharma Sakshy, Hullatti KK. Sachin Kumar, Tiwari KR. Brijesh. Comparative antioxidant activity of Cuscutareflexa and Cassythafiliformis. Journal of Pharmacy Research 2012; 5(1), 441-443.
[24] Sheth UK, Dadkar NK, Kamath NG. Selected topics inexperimentalpharmacology. Vol 5, Kothari Book Depot,Bombay, India, 1972, 63.
[25] Shilpkar P. an alternate use of calotropisgigantea: biomethanation. Current science 2007, 92(4); 435-437.
[26] Tripathi KD. Essentials of Medical Pharmacology. 5th Ed. New Delhi: Jaypee Brothers Medical Publishers; 2003.
[27] Warrier, P.K., V.P.K Nambiar, and C. Mankutty 1994. Indian Medicinal Plants. Oriet Longman; Chennai, India p. 341‐345.
[28] Vizi ES. 1988, Receptor- mediated local fine-tuning by noradrenergic innervations of neuroendocrine and immune systems. Ann N Y AcadSci; 851: 388-396.http://dx.doi.org/10.1111/j.1749-6632.1998.tb09012.x.
[29] Watikins LR, Maier SF, Goehler LE. 1995, Cytokine-to-brain communication: a review and analysis of alternative mechanisms. Life Science;57:1011-1026http://dx.doi.org/10.1016/0024-3205(95)02047-M.
[30] Zhou, D. H.; Berger, J.; Clerk, D,; Sethofer, S.G.; Krauss, N. e,;Brothers, J. M.; Martin, TR. S.; Misner, D. L.; Schwabd, D,; Alexandrovad, L.2007, Bioorg. Med. ChemLett. 17, 3504.http://dx.doi.org/10.1016/j.bmcl.2006.12.093.