Anti-epileptic potentials of the partitioned fractions of chamaecrista mimosoides

  • Authors

    • Asinamai N. Medugu Department of Pure and Applied Chemistry, Faculty of Science, University of Maiduguri, Maiduguri, Borno State
    • James Yakubu Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Maiduguri, Maiduguri, Borno State
    • Hussaini I. Marte Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Maiduguri, Maiduguri, Borno State
    • Timothy . Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Maiduguri, Maiduguri, Borno State
    • S. Yerima Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Maiduguri, Maiduguri, Borno State
    2020-07-25
    https://doi.org/10.14419/ijpt.v8i1.30785
  • Chamaecrista mimosoides Phytochemical Antiepileptic, Pentylenetetrazole (PTZ), Maximal Electroshock Induced Seizure (MEST), Strychnine

  • This research work aimed to establish scientific basis for the use of Chamaecrista mimosoides, in traditional medicine as anti-epileptic medication. The whole plant part of Chamaecrista mimosoides was extracted with ethanol and screened for phytochemicals. Acute toxicity study was carried out using Lorke’s method and the antiepileptic activity was evaluated using maximal electroshock induced seizure test in day-old chicks, pentylenetetrazole (PTZ) and strychnine using mice. The phytochemical study revealed the presence of saponins, cardiac glycosides, tannins, flavonoids, terpenoids and cardenolides. Both the chloroform, ethylacetate and n-butanol portions at 100, 250, and 500mg/kg body weight did not protect the chicks against tonic hind limb extension (THLE) in maximal electro-shock test (MEST). The chloroform and n-butanol portions at doses of 250 and 500 mg/kg body weight protected 40% and 60% of mice against clonic spasm induced by pentylenetetrazole, while ethyl-acetate soluble portion did not protect the mice against clonic spasm induced by pentylenetetrazole at all doses used when compared to Valproic acid (200 mg/kg) protected all the mice (100%) against clonic spasm induced by pentylenetetrazole. The chloroform soluble portion at the doses of 100, 250 and 500 mg/kg body weight protected 40%, 100%, 100% against death induced by strychnine, while ethylacetate and n-butanol portions did not protect the rats against death induced by strychnine but prolonged the onset of convulsion. In all the tests, phenobarbitone (20 mg/kg) was used as positive control and protected 80% of mice against convulsion induced by strychnine. The antiepileptic investigation suggests that the chloroform portion of Chamaecrista mimosoides has a promising antiepileptic activity.

     

     

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  • How to Cite

    N. Medugu, A., Yakubu, J., I. Marte, H., ., T., & Yerima, S. (2020). Anti-epileptic potentials of the partitioned fractions of chamaecrista mimosoides. International Journal of Pharmacology and Toxicology, 8(1), 89-95. https://doi.org/10.14419/ijpt.v8i1.30785