Potential anti-diabetic property of the aqueous extract of the leaves of Saba senegalensis Pichon (apocynaceae) in mice

  • Authors

    • Dosso Mamadou Peleforo Gon coulibaly University
    • coulibaly Adama Peleforo Gon Coulibaly University
    • Coulibaly Ousmane Félix Houphouët-Boigny National Polytechnic Institute (INP-HB
    • Soro Doudjo Félix Houphouët-Boigny National Polytechnic Institute (INP-HB)
    • N'guessan J. David Félix Houphouët-Boigny University
    2020-05-16
    https://doi.org/10.14419/ijpt.v8i1.30635
  • Saba Senegalensis, Antidiabetic, Hypoglycemic, Antihyperglycemic, Mouse.

  • This study made it possible to demonstrate that Saba senegalensis has hypoglycemic and anti-hyperglyvemic effects in mice. The aqueous extract of Saba senegalensis from 75 to 250 mg / Kg bw causes a dose-dependent hypoglycemia ranging from 4.84 to 34.62% (p <0.01-0.05), in normoglycemic mice, 60 minutes after treatment. The Glucose-Induced Hyperglycemia Orally (OPGH) test showed that in the presence of Saba senegalensis aqueous extract at a concentration between 75 and 250mg/Kg bw, the glucose-induced hyperglycemic peak (3g/Kg bw) is reduced from 26.49 to 71.77% (p < 0.01-0.05), 30 minutes after treatment. Oral administration of the aqueous extract of this plant in doses up to 5000 mg / Kg bw resulted in no deaths in mice during two weeks of observation.

     

     

     


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    Mamadou, D., Adama, coulibaly, Ousmane, C., Doudjo, S., & J. David, N. (2020). Potential anti-diabetic property of the aqueous extract of the leaves of Saba senegalensis Pichon (apocynaceae) in mice. International Journal of Pharmacology and Toxicology, 8(1), 65-69. https://doi.org/10.14419/ijpt.v8i1.30635