Health impact of toxic metals in facial cosmetics used in Calabar, Nigeria

  • Authors

    • Julius UkoNaku Department of General Studies College of Health Technology, Calabar Nigeria
    • Bassey E. Inah Department of Chemistry, Universityof Calabar
    • Dominic A. Mowang Department of Environmental Biology, University of Calabar
    • Terngu P. Ugosor Department of Chemistry, College of Education Katsina-Ala
    2020-02-08
    https://doi.org/10.14419/ijpt.v8i1.30141
  • Concentration, Contamination, Cosmetics, Percutaneous Absorption, Toxic.
  • The present study highlights the health risk factor of heavy metals in cosmetics considering their habitual use in the society today. This safety assessment has become inevitable because of the high demand for these products which has resulted to flooding the markets with low quality cosmetics. Digestion was by 20 mL mixture of nitric acid (HNO3) and hydrogen peroxide (H2O2) in the ratio of 3:1 and was heated in a hot plate for 2-3 hours at 90 °C. The choice of this mixture was informed by literature to yield the highest amounts in metal digestion. The mean metal concentrations of these products are; 1.2758, 0.9599, 0.1262, 0.0504 and 0.0068 mg/kg while the ranges are: 0.140-5.823, 0.054-3.908, 0.021-0.820, 0.028-0.071 and 0.001-0.236 mg/kg respectively for Mn, Ni, Cr, Cd and Pb. From the analysis, 40 %, 74.28 %, and 17.14 % of the products has Cd, Ni and Mn respectively exceeded the standard. Pb was not detected in majority of the products. Though cosmetic safety cannot be ascertained only by their heavy metal content, the present paper focuses solely on the contribution of heavy metals as a risk factor to the consumption of these products.

     

     


     
  • References

    1. [1] Ackah M, J. Osei, A. K. Anim, N. Zakaria, E.S. Nyarko, E. T. Gyamfi, S. Enti-Brown, J.E.K. Hanson, N.O.Bentil and D. Tulasi (2015). Status of Some Metals Contained in Imported Nail Polish and Lipsticks on the Ghanian Market. Proceedings of the International Academy of Ecology and Environmental Sciences 5 (4):142-147.

      [2] Agency for Toxic Substance and Disease Registry (2014). The Priority List of Hazardous Substances that will be the subject of Toxicological profile. http://www.atsdr.cdc.gov/spl (accessed on 20 July 2019).

      [3] Agency for Toxic Substances and Disease Registry (2012). Toxicological profile for Chromium. Atlanta, GA: US Public Health Service.

      [4] Ahmad A, M.H Sayed, S. Barua, M.H.Khan, M.H.Faruquee, A.Jalil, S.A.Hadi and H.K.Talukder (2001). Arsenal in drinking water and pregnancy outcome. Environmental Health Perspectives 109: (6) 29-97.https://doi.org/10.1289/ehp.01109629.

      [5] Al-Bader A, Omu AE, and Dasti H (1999). Chronic Cadmium Toxicity to Sperm of Heavy Cigarette Smokers: Immunomodulation by Zinc. Archives of Andrology; 43 (3):135-140.https://doi.org/10.1080/014850199262643.

      [6] Aldayel O, Hefne J, Alharbi and Al-jyan T (2018). Heavy metal concentrations in facial cosmetics. Natural product chemistry and Research 6: (1) 1-9.

      [7] ASEAN Guidelines on limits of cosmetics; ASEAN Cosmetic Scientific Body (ACSB) Meeting 2nd-3rd May 2017, Siem Reap, Cambodiaand endorsed at the 26th ASEAN Cosmetic Committee (ACC) MEETING 4th-5thMay2017, Siem Reap, Cambodia. https://www.hsa.gov.sg/.../Cosmetic.../ASEAN%20Guidelines%20on%20Limits%20of.

      [8] Bellinger CD (2008). Very low lead exposures and children’s neurodevelopment. Therapeutics and Toxicology 20: 172-177.https://doi.org/10.1097/MOP.0b013e3282f4f97b.

      [9] Bellinger CD (2005). Terotogen Update: Lead and Pregnancy. Clinical and Molecular Teratology 73:409-420.https://doi.org/10.1002/bdra.20127.

      [10] Campaign for Safe Cosmetics (2007). A poison kiss: the problem of lead in lipsticks. www.safecosmetics.org.

      [11] Chan, E (2012) Health Canada Published Guidelines on Heavy Metal Impurities in Cosmetics. Sparkle Volume 63.

      [12] Available online: http://www.intertek.co.th/uploadedFiles/Intertek/Divisions/Consumer_Goods/.

      [13] Media/PDFs/Sparkles/2012/sparkle632.pdf (accessed on 26 July 2019).

      [14] Chia SE, Xu B, Ong CN, Tsakok FM and Lee ST (1994). The effects of cadmium and cigarette smoking on human semen quality. International Journal of fertility and menopausal studies. 9: 292-298.

      [15] Dickson H, Parker L (1994). Do alcohol and lead change the sex ratio? Journal of Theoretical Biology 169: 313-315.https://doi.org/10.1006/jtbi.1994.1152.

      [16] Dykeman R, Aguila-Madrid G, Smith T (2002). Lead exposure in Mexico Radiator Repair Workers. American Journal of Industrial Medicine 41: 179-187.https://doi.org/10.1002/ajim.10044.

      [17] Eibensteine L, Delcarsanz A, Frumkin H, Lead exposure and semen quality among traffic police in Arequipa, Peru. International Journal of Occupational and Environmental Health 11: (1) 166-170.https://doi.org/10.1179/oeh.2005.11.2.161.

      [18] Encyclopaedia Encarta (2009), DVD. Redmond, WA; Microsoft Corporation 2008.

      [19] Fagher U, Laudanski T, Schutz A, Sipowicz M, Akerlund M (1993). The relationship between cadmium and lead burdens on preterm labour. International Journal of Gynaecology and Obstetrics 40: 109-114.https://doi.org/10.1016/0020-7292(93)90368-7.

      [20] Henson MC, Chedrese PJ (2004). Endocrine disruption by cadmium, a common environmental toxicant with paradoxical effects on reproduction. Experimental Biology and Medicine 229 (5): 383-392.https://doi.org/10.1177/153537020422900506.

      [21] Hostynek J (2003). Factors determining percutaneous metal absorption. Food Chemistry and Toxicology 41: 327-345.https://doi.org/10.1016/S0278-6915(02)00257-0.

      [22] International Agency for Research on Cancer (IARC, 2012). Arsenic, metals, fibres and dusts. IARC monograph on the Evaluation of Carcinogenic Risks to Humans 100 (PtB) :1-441.

      [23] Itai Y, Fujino T, Ueno K and Motomatsu Y (2004). An Epidemiological Study of the Incidence of Abnormal Pregnancy in Areas Infected Heavily with Contaminated Methylmercury. Environmental Science 11 (2): 83-97.

      [24] James WH (2006). Offspring sex ratios at birth as markers of potential endocrine disruption. Environmental Resources 100: 77-85. https://doi.org/10.1016/j.envres.2005.03.001.

      [25] Jana K, Jana S, Samanta PK (2006). Effects of Chronic exposure to sodium arsenite on hypothalamo-pituitory-testicular activities in adult rats: possible an estrogen mode of action. Reproductive Biology and Endocrinology 4: 9.https://doi.org/10.1186/1477-7827-4-9.

      [26] Joint FAO/WHO Expert Committee on Food Additives. Meeting. (57th: Rome, Italy, 2001). Safety Evaluation of Certain Food Additives and Contaminants/Prepared by the Fifty-Seventh Meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA); World Health Organization: Geneva, Switzerland, 2002.

      [27] Available online: https://www.who.int/foodsafety/areas_work/chemical-risks/jecfa/en/ (accessed on 26 July 2019).

      [28] Jolibois LS, Shi W, George WJ, Henson MC, Anderson M.B (1999). Cadmium accumulation and effects on progesterone released by cultured human trophoblast cells. Reproductive Toxicology 13 (3): 215-21.https://doi.org/10.1016/S0890-6238(99)00009-X.

      [29] Jolibois LS, Burow ME, Swan KF, George WJ, Anderson MB, Henson MC (1999). Effects of cadmium on cell viability, trophoblastic development and expression of low density lipoprotein receptor transcripts in cultured human placental cells. Reproductive Toxicology, 13 (6):473-80. https://doi.org/10.1016/S0890-6238(99)00041-6.

      [30] Larese FF, Boeniger M, Maina G, Spinelli P, and Damian A (2006). Skin absorption of inorganic lead (PbO) and the effects of skin cleansers. Journal of Occupational and Environmental Medicine 48: 692.https://doi.org/10.1097/01.jom.0000214474.61563.1c.

      [31] Larese F, Fiorito A, Adami G (1999). Skin absorption in vitro of glycol ethers. International Archives of Occupational and Environmental Health, 72 (7): 480-484.https://doi.org/10.1007/s004200050402.

      [32] Liu S, Hammond SK, Rojas-cheathan A (2013). Concentrations and Potential Health Risks of Metals in Lip products. Environmental Health Perspectives. 121 (6) 705-710.https://doi.org/10.1289/ehp.1205518.

      [33] Livingstone C, Collison M (2002). Sex steroids and insulin resistance. Clinical science, London 102: 151-166.https://doi.org/10.1042/cs1020151.

      [34] Mendola P, Messer LC, and Rappazzo K (2008). Science Linking Environmental Contaminant Exposure with Fertility and Reproductive Health Impacts in Adult Female. Fertility and Sterility 89: (1) 81-93.https://doi.org/10.1016/j.fertnstert.2007.12.036.

      [35] Miranda M L, Kim D, Galeano M A, Paul C J, Hull A P (2007) The relationship between early childhood blood lead levels and performance on end-of-grade tests. Environmental Health Perspective 115: 1242-1247.https://doi.org/10.1289/ehp.9994.

      [36] Nasirudeen MB and Amaechi AU (2015). Spectrophotometric Determination of Heavy Metals in Cosmetics Sourced from Kaduna Metropolis, Nigeria. Science World Journal 10 (3) 1-5.

      [37] Nishijo M, Nakagawa H, Honda R, Tanabe K, Saito S, Teranishi H, Tawara K (2002). Effects of maternal exposure to cadmium on pregnancy outcome and breast milk. Occupational and Environmental Medicine 59: 394-397.https://doi.org/10.1136/oem.59.6.394.

      [38] Official Journal of the European Union. Regulation (EC) No 1881/2006 of 19 December 2006 on Setting Maximum Levels for Certain Contaminants in Foodstuffs. 2006. Available online: https://eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri=CELEX:32006R1881&from=EN (accessed on 26 July 2019).

      [39] Orisakwe O E and Otaraku JO (2013). Metal concentrations in cosmetics commonly used in Nigeria. The scientific world Journal. Volume 2013, Article ID 959637, 7 pages.https://doi.org/10.1155/2013/959637.

      [40] Rowland AS, Baird DD, Weinberg CR (1994). The Effects of Occupational Exposure to Mercury Vapour on Fertility of Female Dental Assistant. Occupational and Environmental Medicine 51: 28-34.https://doi.org/10.1136/oem.51.1.28.

      [41] Sahu R, Saxena P, Johnson S (2014). “Heavy Metals in cosmetic. Centre for Science and Environmentâ€. 1:1-28.

      [42] Sainic EL, Jolanki R, Hakala E and Kanerva L (2001). Metals and Arsenic in eye shadows. Contact Dermatitis 42 (1): 5-10.https://doi.org/10.1034/j.1600-0536.2000.042001005.x.

      [43] Sani A, Maryam BG, Abubakar FA (2016). Determination of Some Heavy Metals in Selected Cosmetic Products sold in Kano Metropolis, Nigeria. Toxicology Reports 1:1-9.https://doi.org/10.1016/j.toxrep.2016.11.001.

      [44] Saxena D K, Singh C, Murthy RC (1994). Blood and placental lead levels in an Indian City: A preliminary report. Archives of Environmental Health, 49 (2): 106-110.https://doi.org/10.1080/00039896.1994.9937462.

      [45] Selevan SG, Rice DC, Hogan K A, Euling SY (2003). Blood lead concentration and delayed puberty in girls. North England Journal of Medicine 348 (15) 27-36.https://doi.org/10.1056/NEJMoa020880.

      [46] Shaltout A, Yaish SA, Fernando N (1981). Lead encephalopathy in infants in Kuwait: A study of 20 infants with particular reference to clinical presentation and source of lead poisoning. Annual tropical Pediatric 1: 209-215. https://doi.org/10.1080/02724936.1981.11748090.

      [47] Talisman S, Cvitkovic P, Jurasovic J, (2000). Semen quality and reproductive endocrine function in relation to biomarkers of lead, cadmium, zinc and copper in man (2000). Environmental Health Perspective 108: 45-50.https://doi.org/10.1289/ehp.0010845.

      [48] Tang N, and Zhu ZQ (2003). Adverse reproductive effects in female workers of lead battery plant. International Journal of Occupational Medicine and Environmental Health 16 (3) 59-61.

      [49] Tseng GH (2005). Blackfoot disease and arsenic: a never ending story. Journal of Environmental Science and Health 23 55-74.https://doi.org/10.1081/GNC-200051860.

      [50] Ullah Hussain, Shamsa Noreen, Fozia, Ali Rehman, Amir Waseem, Shumaila Zubair, Muhammad Adnan, Ijaz Ahmad (2017). Arabian Journal of Chemistry 10: 10-18.https://doi.org/10.1016/j.arabjc.2013.09.021.

      [51] U.S. Food and Drug Administration. FDA’s testing of Cosmetics for Arsenic, Cadmium, Chromium, Cobalt, Lead, Mercury, and Nickel Content. 2018. Available online: https://www.fda.gov/Cosmetics/ProductsIngredients/PotentialContaminants/ucm452836.htm (accessed on 26 July 2019.

      [52] Waalkes MP, Keefer LK, Diwan BA (2000). Induction to proliferation lesions of the uterus, testis and liver in Swiss mice given repeated injections of sodium arsenate: possible mode of action. Toxicology and Applied Pharmacology 166: 24-35.https://doi.org/10.1006/taap.2000.8963.

      [53] Wang CL, Chuan HY, Ho CK, Yang CY, Tsai J.L, Wu TS and Wu TN (2002). The relationship between blood lead concentration and learning achievement among primary school children in Taiwan. Environmental Resources 89 (1): 12-18.https://doi.org/10.1006/enrs.2002.4342.

      [54] Whitehouse L, Germany Reduces Heavy Metal Limits in Cosmetics. 2017. Available online: https://www.cosmeticsdesign-europe.com/Article/2017/07/25/Germany-reduces-heavy-metal-limits-in-cosmetics (accessed on 25 July 2019.

      [55] Wu T, Buck GM, Mendola P (2003). Blood lead levels and sexual maturation in US girls. The third National Health and Nutrition Examination Survey. Environmental Health Perspective 111 (7) 37-41.

      [56] Yang CY, Sung F (2006). Low blood lead concentration in association with infertility in women. Environmental Resources 101 (38) 1-6.

      [57] Zhai H, Maibach H, (2001). Effects of skin occlusion on percutaneous absorption. An overview: skin pharmacology and applied skin physiology 14: 1-10.https://doi.org/10.1159/000056328.

  • Downloads

  • How to Cite

    UkoNaku, J., E. Inah, B., A. Mowang, D., & P. Ugosor, T. (2020). Health impact of toxic metals in facial cosmetics used in Calabar, Nigeria. International Journal of Pharmacology and Toxicology, 8(1), 29-35. https://doi.org/10.14419/ijpt.v8i1.30141