Extraction of Flavonoids from Flavedo Layers of Citrus Fruits Peels and its Expected Anti-Diabetic and Psychological Significance; a Biochemical and Family Medicine Overview

  • Authors

    • Abdelgadir M. I
    • Suliman H.M
    2023-10-06
    https://doi.org/10.14419/ijm.v11i1.32312

  • This study was aimed at the Extraction of Flavonoids from Albedo layers of citrus fruits peels and its expected anti-diabetic significance. Lemon (Citrus limon) is the third most important species of citrus after orange and mandarin. Flavedo is the peel’s outer layer. It is a rich source of essential oils. Albedo extract was separated. Study results clearly showed the presence (p ≤ 0.05) of flavonoids in Albedo citrus layers; peel > pulp > seeds. Flavonoids are the major constituents of dry citrus fruits as well as citrus peels. Citrus fruit prevents free radical generation and reduces homocysteine level; it also possesses anti-carcinogenic, anti-diabetic, anti-inflammatory properties. Flavonoids applications in medicinal chemistry includes anticancer, antioxidant, anti-inflammatory, and antiviral properties. They also have neuroprotective and cardio-protective effects.

  • References

    1. A. Fejzić, S. Ćavar, Phenolic Compounds and Antioxidant Activity of Some Citruses. Bull. Chem. Technol. Soc. Bosnia Herzegovina 42 (2014) 1-4.
    2. A. Sass-Kiss, M. Toth-Markus, M. Sass, Chemical Composition of Citrus Fruits (Orange, Lemon and Grapefruit) with Respect to Qual-ity Control of Juice Products. In: Shahidi F (ed). Nutraceutical Beverages: Chemistry Nutrition, and Health Effects. Washington DC: American Chemical Society (2004) 24-34. https://doi.org/10.1021/bk-2004-0871.ch003.
    3. B.B. Li, B. Smith, M.M. Hossain, Extraction of phenolics from citrus peels: I. Solvent extraction method. Sep. Purif. Technol 48 (2006) 182–188. https://doi.org/10.1016/j.seppur.2005.07.005.
    4. C.S. Hif, S.L. Howell, Effects of epicatechin on rat islets of langerhans. Diabetes 33 (1984) 291-296. https://doi.org/10.2337/diabetes.33.3.291.
    5. C.S. Hif, S.L. Howell, Effects of flavonoids on insulin secretion and 45 Ca+2 handling in rat islets of langerhans. J. Endocrinol 107 (1985) 1-8. International Diabetes Federation (IDF), Diabetes Atlas, third edition, 2006. http://www.diabetesatlas.org/. Accessed on 02/08/2010. https://doi.org/10.1677/joe.0.1070001.
    6. D. Barreca, G. Laganà, S. Ficarra, et al. Evaluation of the antioxidant and cytoprotective properties of the exotic fruit Annona cherimola Mill. (Annonaceae), Food Research International 44 (7) (2011) 2302-2310. ISSN 0963-9969, https://doi.org/10.1016/j.foodres.2011.02.031.
    7. D. Zema, P. Calabrò, A. Folino, et al. Valorisation of citrus processing waste: A review J. Waste Manag. 80 (2018) 252-273. https://doi.org/10.1016/j.wasman.2018.09.024.
    8. E. González-Molina, R. Domínguez-Perles, D.A. Moreno, C. García-Viguera, Natural bioactive compounds of Citrus limon for food and health. J. Pharm. Biomed. Anal 51 (2010) 327–345. https://doi.org/10.1016/j.jpba.2009.07.027.
    9. J.J. Peterson, J.T. Dwyer, G.R. Beecher, et al. Flavanones in oranges, tangerines (mandarins), tangors, and tangelos: A compilation and review of the data from the analytical literature. J. Food Compos. Anal 19 (2006) S66–S73. https://doi.org/10.1016/j.jfca.2005.12.006.
    10. J.M. Ortiz, Botany: Taxonomy, Morphology and Physiology of Fruits, Leaves and Flowers. In: Dugo G and Di Giacomo A (eds). Cit-rus: The Genus Citrus. London; New York: Taylor and Francis (2002)16-35.
    11. K.A. Sir Elkhatim, R.A. Elagib, A.B Hassan, Content of phenolic compounds and vitamin C and antioxidant activity in wasted parts of Sudanese citrus fruits. Food Sci. Nutr (2018). https://doi.org/10.1002/fsn3.660.
    12. K. Datta, S. Sinha, Chattopadhyay, P. Reactive oxygen species in health and disease. Natl Med J India 13 (6) (2000) 304-310.
    13. L. Aleson-Carbonell, J. Ferna´ndez-Lo´pez, J.A. Pe´rez-A´lvarez, V. Kuri, Characteristics of beef burger as influenced by various types of lemon -albedo. Innovat Food Sci Emerg Tech 6 (2) (2005) 247–255. https://doi.org/10.1016/j.ifset.2005.01.002.
    14. M.A. Awad, A. de Jager, L.H.W. van der Plas, A.R. van der Krol, Flavonoid and chlorogenic acid changes in skin of ‘Elstar’ and ‘Jon-agold’apples during development and ripening. Sci. Hortic 90 (2001) 69–83. https://doi.org/10.1016/S0304-4238(00)00255-7.
    15. M.L. Chen, D.J. Yang, S.C. Liu, Effects of drying temperature on the flavonoid, phenolic acid and ant oxidative capacities of the meth-anol extract of citrus fruit (Citrus sinensis (L.) Osbeck) peels. International Journal of Food Science & Technology 46 (2011) 1179-1185. https://doi.org/10.1111/j.1365-2621.2011.02605.x.
    16. M. Morley-Bunker, Citrus. In: Jackson DI and Looney NE (eds). Temperate and Subtropical Fruit Production, 2nd Edition. New York, Wallingford: CABI Publishing (1999) 229-239.
    17. M. Vessal, M. Hemmati, M. Vasei, Antidiabetic effects of quercetin in streptozocin-induced diabetic rats, Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 135 (3) (2003) 357-364. ISSN 1532-0456, https://doi.org/10.1016/S1532-0456(03)00140-6.
    18. N. Jamil, R. Jabeen, M. Khan, M. Riaz, T. Naeem. et al. Quantitative assessment of juice content, citric acid and sugar content in orang-es, sweet lime, lemon and grapes available in fresh fruit market of quetta city. International Journal of Basic and Applied Sciences 15 (2015) 21-24.
    19. N. Koolaji, B. Shammugasamy, A. Schindeler, et al. Citrus peel flavonoids as potential cancer prevention agents Current Developments in Nutrition 4 (5) 2020. https://doi.org/10.1093/cdn/nzaa025.
    20. O. Benavente-Garcia, J. Castillo, Update on uses and properties of citrus flavonoids: New findings in anticancer, cardiovascular, and anti-inflammatory activity. J. Agric. Food Chem 56 (2008) 6185–6205. https://doi.org/10.1021/jf8006568.
    21. P. Brat, D. Olle, A.L. Gancel, M. Reynes, J.M. Brillouet, Essential oils obtained by flash vacuum -expansion of peels from lemon, sweet orange, mandarin and grapefruit. Fruits 56 (6) (2001) 395–402. https://doi.org/10.1051/fruits:2001102.
    22. P. Milind, C. Dev, Orange: Range of benefits. Res. J. Pharm 3 (7) 2012 59-63.
    23. S.A. Vekiari, E.E. Protopadakis, P. Papadopoulou, et al. Composition and seasonal variation of the essential oil from leaves and peel of a certain lemon variety. J Agric Food Chem 50 (1) (2002) 147–153. https://doi.org/10.1021/jf001369a.
    24. S.E. Shafekh, R. Khalili, C.C.W. Catherine, et al. Total phenolic content and in vitro antioxidant activity of Vigna sinensis. Food Res. J 19 (4) (2012) 1393-1400.
    25. S.M. Njoroge, N.T. Phi, M. Sawamura, Chemical composition of peel essential oils of sweet oranges (Citrus sinensis) from Uganda and Rwanda. Chede PS. Phytochemical Anal 31, Journal of Essential Oil-Bearing Plants 12 (2009) 26-33. https://doi.org/10.1080/0972060X.2009.10643687.
    26. S.S. Janati, H.R. Beheshti, J. Feizy, N.K. Fahim, Chemical composition of lemon (Citrus limon) and peels its considerations as animal food. GIDA Journal of Food 37 (2012) 267-271.
    27. T. Adeel, A. Tariq, Auranzaib, M. Akber, Flavors from Citrus Peels and their Functions in Food. Journal of Food and Dairy Technolo-gy 3 (2015) 5-17.

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    M. I, A., & H.M, S. (2023). Extraction of Flavonoids from Flavedo Layers of Citrus Fruits Peels and its Expected Anti-Diabetic and Psychological Significance; a Biochemical and Family Medicine Overview. International Journal of Medicine, 11(1), 11-14. https://doi.org/10.14419/ijm.v11i1.32312