Effects of various local analgesics and ketamine for cranial epidural analgesia in Black Bengal Goats

  • Authors

    • Animesh Roy Sylhet Agricultural University, Bangladesh
    • Md Islam Sylhet Agricultural University, Bangladesh
    • Mohammed Hossain Sylhet Agricultural University, Bangladesh
    • Nasrin Lucky Sylhet Agricultural University, Bangladesh
    • Md Rashedunnabi Akanda Sylhet Agricultural University, Bangladesh
    • Bashudeb Paul Sylhet Agricultural University, Bangladesh
    • Mir Hasan Sylhet Agricultural University, Bangladesh
    • Md Mahfuz Sylhet Agricultural University, Bangladesh
    • Fokor Uddin Sylhet Agricultural University, Bangladesh
    • Sipra Roy Sylhet Agricultural University, Bangladesh
    2014-12-27
    https://doi.org/10.14419/ijbr.v3i1.3546
  • Effect, Local Analgesics, Ketamine, Cranial Epidural Analgesia, Goats.
  • The present study was conducted to find out the effects of analgesic and anaesthetic drugs for cranial epidural analgesia in Black Bengal goats. A series of thirty two (n=32) analgesic trails were conducted in goats age ranged from 8 to 12 months and with an average body weight of 8.1 kg. The animals were divided into four groups (n=4) and a replication of 8 trails was performed in each group at least one week interval. Two percent (2%) lidocaine hydrochloride (6.0 mg/kg), 2% lidocaine hydrochloride with adrenaline (6.0 mg/kg), 0.5% bupivacaine hydrochloride (1.5 mg/kg) and ketamine hydrochloride (5.0 mg/kg) were used to perform cranial epidural analgesia. 2% Lidocaine hydrochloride and Ketamine hydrochloride showed rapid onset of analgesia. 0.5% bupivacaine hydrochloride produced the highest area of desensitization in thigh region during cranial epidural analgesia. Perineal region and tail were totally desensitized during epidural analgesia. 0.5% bupivacaine hydrochloride prolonged the duration of analgesia during epidural analgesia. 2% Lidocaine hydrochloride showed no side effects whereas 2% Lidocaine hydrochloride with adrenaline showed straining and muscle tremor, 0.5% bupivacaine hydrochloride shivering and drowsiness, ketamine hydrochloride tympany, excitement and drowsiness. It seemed that 2% Lidocaine hydrochloride is more effective whereas 0.5% bupivacaine hydrochloride is associated with side effects. Though ketamine hydrochloride is a dissociative agent, it could also be used in epidural analgesia.

  • References

    1. [1] Anubhav K, MR Fazili, RA Shah, MH Bhat, FA Khan, SH Yaqoob, NA Naykoo and NA Ganai (2014). Comparison between lignocaine hydrochloride and ropivacaine hydrochloride as lumbosacral epidural anaesthetic agents in goats undergoing laparoscopy assisted embryo transfer. Mac Vet Rev, 37(2): i-ix.

      [2] Beltman ME, Self I and Duane M (2010). The use of epidural in cattle. Irish Veterinary Journal, 63(1): 51-54.

      [3] Booth NH (1988). Intrathecal and epidural anaesthesia. In: Veterinary pharmacology and Therapeutics. 6th edn. Iowa state University press. pp: 424.

      [4] Brander GC, Pugh DM, Bywater RJ and Jenkins WL (1991). Veterinary Applied Pharmacology and Therapeutics. 5th edn, ISBN, Bailliere Tindall, London. pp: 110-114.

      [5] Carpenter RE, Wilson DV and Evans AT (2004). Evaluation of intraperitoneal and incisional lidocaine or bupivacaine or analgesia following ovarihysterectomy in the dog. Anaesthesia and Analgesia, 31: 46-552. http://dx.doi.org/10.1111/j.1467-2995.2004.00137.x.

      [6] Cousins MJ and Mather JE (1984). Intrathecal and epidural administration of opoid. Anaesthesiology, 61: 276-310. http://dx.doi.org/10.1097/00000542-198409000-00008.

      [7] DeRossi R, Ruzzon RH, Verde-Selva AB and Bertoni RA (2010). Evaluation of segmental dorsolumber epidural analgesia with ketamine hydrochloride administered by use of nonstyletted multiple-port catheters via the caudal approach in cattle. Am j Vet Res, 71(1): 17-23. http://dx.doi.org/10.2460/ajvr.71.1.17.

      [8] Dripps RD, Echenhoff JE and Vandem LD (1988). Introduction to anaesthesia. In: The principles of safe practice. 7th edn, W.B. Saunders Co. Philadelphia pp: 233-235.

      [9] Eugene PS and Nicholas HB (1995). Local anaesthetics. In: Veterinary Pharmacology and Therapeutics. Iowa State University Press. pp: 271-358.

      [10] Gissen AJ, Covino BG and Gregvs J (1980). Differential sensitivity of mammalian nerve fibres to anaesthetic agents. Anaesthesiology, 53: 467-474. http://dx.doi.org/10.1097/00000542-198012000-00006.

      [11] Hall LW and Clarke KW (1989). Veterinary Anaesthesia. 8th edn. Bailliere Tindall, London.

      [12] Hasim MA and Hossain MA 91989). Effect of starvation and positioning on gastroesophageal reflux in anaesthetized goat during chloride hydratemagnisium sulphate anaesthesia. Bangladesh Journal of Scientific and Industrial Research, 24: 62-69.

      [13] Ibrahim MN (2013). Behavioral and analgesic effect of acepromazine maleate, lidocaine hydrochloride alone or in combination of them in lumbosacral epidural injection in sheep. The Iraqi Journal of Veterinary Medicine, 37(2): 232-236.

      [14] Kinjavdekar P and Partap K (2002). Comparison of Ketamine and xylazine for lumbo-sacral epidural analgesia in buffalo calves. Indian Journal of Veterinary Surgery, 21(2): 117.

      [15] K Singh, P Kinjavdekar, Amarpal, HP Aithal, A Gopinathan, GR Singh, AM Pawde and K Prata (2007). Comparison of the analgesic, clinicophysiological and hematobiochemical effects of epidural bupivacaine in healthy and uremic goats. Small Ruminant Research, 71(1-3): 13-20. http://dx.doi.org/10.1016/j.smallrumres.2006.02.009.

      [16] Laishley RS, Morgan and Reynolds F (1988). Effect of Bupivacaine on extradural anaesthesia. British Journal of Anaesthesia, 60: 180-186. http://dx.doi.org/10.1093/bja/60.2.180.

      [17] Lumb WV and Jones EW (1984). Local anaesthesia. In: Veterinary Anaesthesia. Edited by JC Thurmon, WJ Tranquilli and GJ Benson. Lippincott, Williams and Wilkins, Philadelphia, pp: 330-336.

      [18] Mpanduji DG and Ndossi DG (2013). Comparison of analgesia and cardio-pulmonary effects of epidural injection of pathedine and lidocaine in small East African goats. Res. Opin. Anim. Vet. Sci, 3(2): 30-34.

      [19] Perraz, JL and Calvo MB (1991). Pharmacokinetics and distribution of ketamine after extradural administration to dogs. British Journal of Anaesthesia, 67: 310-316. http://dx.doi.org/10.1093/bja/67.3.310.

      [20] R Pathak, K Pratap, Amarpal, P Kinjavdekar, HP Aithal and Pankaj (2012). Comparison of bupivacaine, xylazine and buprenorphine with ketamine combination for spinal analgesia in buffalo calves. Vet world, 5(12): 754-761.

      [21] Rostami M and Vesal N (2012). The effects of adding epinephrine or xylazine to lidocaine solution for lumbosacral epidural analgesia in fat-tailed sheep. J S Afr Vet Assoc, 83(1): 1-7 http://dx.doi.org/10.4102/jsava.v83i1.1.

      [22] RA Runa, MA Hashim, MA Hossain, AAM Bhuyan and MS Alam (2008). Comparative efficacy of analgesic and anaesthetic drugs for high epidural analgesia in Black Bengal goats. Bang J Vet Med, 6(1): 103-106.

      [23] Trim CM (1989). Epidural analgesia with 0.75% Bupivacaine for laparotomy in goats. Journal of American Veterinary Medical Association, 194(9): 1292-1296.

      [24] Wildsmith JAW, Gisen AJ, Gregus J and Covino BG (1985). Differential nerve blocking activity of amino-ester local anaesthetics. British Journal of Anaesthesia, 57: 612-620. http://dx.doi.org/10.1093/bja/57.6.612.

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    Roy, A., Islam, M., Hossain, M., Lucky, N., Akanda, M. R., Paul, B., Hasan, M., Mahfuz, M., Uddin, F., & Roy, S. (2014). Effects of various local analgesics and ketamine for cranial epidural analgesia in Black Bengal Goats. International Journal of Biological Research, 3(1), 19-24. https://doi.org/10.14419/ijbr.v3i1.3546